{"product_id":"biolegend-359904","title":"Biolegend, 359904, PE anti-human CD309 (VEGFR2) Antibody, 100tests","description":"\u003cp\u003eCD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1\/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KDR recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Pal D, et al. 2023. Nat Commun. 14:1129. PubMed Gao S, et al. 2021. Angiogenesis. 24:519. PubMed Nishino K, et al. 2021. Sci Rep. 11:8406. PubMed Downes DJ, et al. 2021. Nat Genet. 53:1606. PubMed Evans WS, et al. 2020. Exp Physiol. 105:1408. PubMed Mifuji K, et al. 2017. Bone Joint Res. 10.1302\/2046-3758.68.BJR-2016-0338.R1. PubMed\u003cbr\u003e\nRRID: AB_2562703 (BioLegend Cat. No. 359903) AB_2562704 (BioLegend Cat. No. 359904)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1\/PDGF receptor family\u003cbr\u003e\nDistribution: Endothelial cells, embryonic tissues\u003cbr\u003e\nLigand\/Receptor: VEGF-A, VEGF-C, and VEGF-D splice isoforms\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers Wiley-Liss A John Wiley \u0026amp; Sons Inc, Publication. 2. Ferrara N and Gerber HP. 2002. Acta. Haematol. 106:148. 3. Murohara T, et al. 1998. Circulation. 97:99.\u003cbr\u003e\nGene ID: 3791\u003cbr\u003e\nUniProt: View information about CD309 on UniProt.org\u003cbr\u003e\nClone: 7D4-6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KDR, Vascular Endothelial Receptor 2 (VEGF-R2, VEGFR2, VEGFR)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862486569129,"sku":"359904","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-359904","provider":"Iright","version":"1.0","type":"link"}