{"product_id":"biolegend-359911","title":"Biolegend, 359911, PE\/Cyanine7 anti-human CD309 (VEGFR2) Antibody, 25tests","description":"\u003cp\u003eCD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1\/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human KDR recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Steimle JD, et al. 2023. Cell Rep. 112665:42. PubMed Qiu J, et al. 2020. Cell Rep. 33:108465. PubMed Gruber MM, et al. 2021. Histochem Cell Biol. 156:363. PubMed Dong Y, et al. 2020. J Leukoc Biol. 108:1711. PubMed Zhou F, et al. 2018. Cancer Manag Res. 0.727083333. PubMed\u003cbr\u003e\nRRID: AB_2563551 (BioLegend Cat. No. 359911) AB_2563552 (BioLegend Cat. No. 359912)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1\/PDGF receptor family\u003cbr\u003e\nDistribution: Endothelial cells, embryonic tissues\u003cbr\u003e\nLigand\/Receptor: VEGF-A, VEGF-C, and VEGF-D splice isoforms\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers Wiley-Liss A John Wiley \u0026amp; Sons Inc, Publication. 2. Ferrara N and Gerber HP. 2002. Acta. Haematol. 106:148. 3. Murohara T, et al. 1998. Circulation. 97:99.\u003cbr\u003e\nGene ID: 3791\u003cbr\u003e\nUniProt: View information about CD309 on UniProt.org\u003cbr\u003e\nClone: 7D4-6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KDR, Vascular Endothelial Receptor 2 (VEGF-R2, VEGFR2, VEGFR)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862486962345,"sku":"359911","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-359911","provider":"Iright","version":"1.0","type":"link"}