{"product_id":"biolegend-360306","title":"Biolegend, 360306, PE anti-human CD213a2 (IL13Rα2) Antibody, 100tests","description":"\u003cp\u003eCD213a2, also known as IL13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Rα2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1\/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes, and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human IL-13R alpha 2 Fc chimera\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for relevant formats) include: Western blotting1, ELISA1, immunohistochemistry staining of frozen tissue sections1, and blocking (competes with IL-13 for binding).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Balyasnikova IV, et al. 2012. J. Biol. Chem. 287:30215. (WB, ELISA, IHC, Block)\u003cbr\u003e\nProduct Citations: Wen Y, et al. 2020. J Invest Dermatol. . PubMed\u003cbr\u003e\nRRID: AB_2562620 (BioLegend Cat. No. 360305) AB_2562621 (BioLegend Cat. No. 360306)\u003cbr\u003e\nStructure: Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain\u003cbr\u003e\nDistribution: Activated B cells, fibroblasts, smooth muscle cells, keratinocytes\u003cbr\u003e\nFunction: Possible decoy receptor, antagonist of CD213a1, internalization of IL-13\u003cbr\u003e\nLigand\/Receptor: IL-13\u003cbr\u003e\nCell Type: B cells, Fibroblasts\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Mitchell J, et al. 2010. Curr. Opin. Investig Drugs. 11:527. 2. Strober W, et al. 2009. Curr. Mol. Med. 9:740. 3. Tabata Y and Khurana Hershey GK. et al. 2007. Curr. Allergy Asthma Rep. 7:338.\u003cbr\u003e\nGene ID: 3598\u003cbr\u003e\nUniProt: View information about CD213a2 on UniProt.org\u003cbr\u003e\nClone: 47\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL13BP, CT19\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862406484137,"sku":"360306","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-360306","provider":"Iright","version":"1.0","type":"link"}