{"product_id":"biolegend-360803","title":"Biolegend, 360803, PE anti-human CXCL16 Antibody, 25tests","description":"\u003cp\u003eCXCL16, a 27 kD chemokine, exists in membrane-bound and soluble forms.  Unlike classic chemokines, CXCL16 possesses a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail with a tyrosine phosphorylation domain, allowing it to be expressed on the cell surface.  Structurally, it is similar to fractalkine.  It is expressed by dendritic cells, monocytes, and T cells.  T cells can also migrate in response to CXCL16. CXCL16 can also act as a scavenger receptor on macrophages. Its receptor is CXCR6\/Bonzo.  It can bind oxidized LDL and thus may play an important role in atherosclerosis.  Recent studies have shown a role for CXCL16 in kidney fibrosis and in autoimmunity.  CXCL16 is also a co-receptor for HIV.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified human SR-PSOX-Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats of this clone) include: in vitro blocking of chemotactic activity of CXCR6 expressing cells1. Clone 22-19-12 recognizes the chemokine domain of CXCL16 and has been shown to inhibit chemotactic activity to CXCR6-expressing cells by soluble CXCL16.1\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Shimaoka T, et al. 2003. J. Immunol. 171:1647. (FC, Block)\u003cbr\u003e\nProduct Citations: Durbin SV, et al. 2018. ACS Omega. 16882:3. PubMed Gouwy M, et al. 2016. PLoS One. 11:e0166006. PubMed\u003cbr\u003e\nRRID: AB_2563010 (BioLegend Cat. No. 360803) AB_2563011 (BioLegend Cat. No. 360804)\u003cbr\u003e\nStructure: ~27 kD, exists as a membrane bound and soluble forms\u003cbr\u003e\nDistribution: Produced by dendritic cells and T cells\u003cbr\u003e\nFunction: Binds to oxidized LDL and may play an important role in atherosclerosis\u003cbr\u003e\nInteraction: Interacts with CXCR6\/Bonzo\u003cbr\u003e\nLigand\/Receptor: CXCR6\u003cbr\u003e\nCell Type: Dendritic cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Matloubian M, et al. 2000. Nat. Immunol. 1:298. 2. Wilbanks A, et al. 2001. J. Immunol. 166:5145. 3. Shimaoka T, et al. 2003. J. Immuniol. 171:1647. 4. Chandrasekar B, et al. 2004. J. Biol. Chem. 179:3188. 5. Shimaoka T, et al. 2004. J. Leukoc. Biol. 75:267.\u003cbr\u003e\nGene ID: 58191\u003cbr\u003e\nUniProt: View information about CXCL16 on UniProt.org\u003cbr\u003e\nClone: 22-19-12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SRPSOX, CXCXLG16, SR-PSOX\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860869009577,"sku":"360803","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-360803","provider":"Iright","version":"1.0","type":"link"}