{"product_id":"biolegend-369905","title":"Biolegend, 369905, APC anti-human CD120a Antibody, 25tests","description":"\u003cp\u003eCD120a, also known as tumor necrosis factor receptor type 1 (TNF-R1) is 55 kD member of tumor necrosis receptor superfamily (TNFRSF) which which upon binding tumor necrosis factor alpha (TNFα), homotrimerizes  to interact death domain of TRADD. CD120a, in association with TRADD, leads to activation of NF-κB signaling, in addition to apoptotic and inflammatory responses.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length human CD120a transfectant cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Menevse AN, et al. 2023. Acta Neuropathol Commun. 11:75. PubMed Rohwedder I, et al. 2023. JCI Insight. 8: . PubMed Queckborner S, et al. 2020. Stem Cell Res Ther. 11:15. PubMed Hurrell BP, et al. 2019. Cell Rep. 29:4509. PubMed Hackel A, et al. 2021. Eur J Immunol. 51:319. PubMed\u003cbr\u003e\nRRID: AB_2650763 (BioLegend Cat. No. 369905) AB_2650764 (BioLegend Cat. No. 369906)\u003cbr\u003e\nStructure: 55 kD, single pass type 1 membrane protein, TNFR superfamily.\u003cbr\u003e\nDistribution: Granulocytes, monocytes, and lymphocytes.\u003cbr\u003e\nFunction: Homotrimerizes upon binding TNF, activates apoptotic and NFkB signaling.\u003cbr\u003e\nLigand\/Receptor: TNFα, LTα (TNFβ)\u003cbr\u003e\nCell Type: Eosinophils, Granulocytes, Lymphocytes, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Loetscher H, et al. 1990. Proc. Natl. Acad. Sci. USA 87:3127. 2. Crowe PD, et al. 1994. J. Immunol. 264:707. 3. Aggarwal BB, et al. 1985. J. Biol. Chem. 260:2345. 4. Chan FK, et al. 2000. Science. 288:2351. 5. Sugano M, et al. 2002. Atherosclerosis 162:77. 6. Cottin V, et al. 2002. J. Immunol. 168:4095. 7. Barnhart BC, Peter ME. 2003. Cell. 114:148.\u003cbr\u003e\nGene ID: 7132\u003cbr\u003e\nUniProt: View information about CD120a on UniProt.org\u003cbr\u003e\nClone: W15099A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFR-I, TNFRSF1A, P55, P60\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866298044585,"sku":"369905","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-369905","provider":"Iright","version":"1.0","type":"link"}