{"product_id":"biolegend-369908","title":"Biolegend, 369908, Biotin anti-human CD120a Antibody, 100μg","description":"\u003cp\u003eCD120a, also known as tumor necrosis factor receptor type 1 (TNF-R1) is 55 kD member of tumor necrosis receptor superfamily (TNFRSF) which which upon binding tumor necrosis factor alpha (TNFα), homotrimerizes  to interact death domain of TRADD. CD120a, in association with TRADD, leads to activation of NF-κB signaling, in addition to apoptotic and inflammatory responses.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length human CD120a transfectant cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Herati RS, et al. 2021. Cell Reports Medicine. 2(5):100262. PubMed Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed\u003cbr\u003e\nRRID: AB_2650932 (BioLegend Cat. No. 369908)\u003cbr\u003e\nStructure: 55 kD, single pass type 1 membrane protein, TNFR superfamily.\u003cbr\u003e\nDistribution: Granulocytes, monocytes, and lymphocytes.\u003cbr\u003e\nFunction: Homotrimerizes upon binding TNF, activates apoptotic and NFkB signaling.\u003cbr\u003e\nLigand\/Receptor: TNFα, LTα (TNFβ)\u003cbr\u003e\nCell Type: Eosinophils, Granulocytes, Lymphocytes, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Loetscher H, et al. 1990. Proc. Natl. Acad. Sci. USA 87:3127. 2. Crowe PD, et al. 1994. J. Immunol. 264:707. 3. Aggarwal BB, et al. 1985. J. Biol. Chem. 260:2345. 4. Chan FK, et al. 2000. Science. 288:2351. 5. Sugano M, et al. 2002. Atherosclerosis 162:77. 6. Cottin V, et al. 2002. J. Immunol. 168:4095. 7. Barnhart BC, Peter ME. 2003. Cell. 114:148.\u003cbr\u003e\nGene ID: 7132\u003cbr\u003e\nUniProt: View information about CD120a on UniProt.org\u003cbr\u003e\nClone: W15099A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFR-I, TNFRSF1A, P55, P60\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866298077353,"sku":"369908","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-369908","provider":"Iright","version":"1.0","type":"link"}