{"product_id":"biolegend-373009","title":"Biolegend, 373009, PE\/Cyanine7 anti-human GPR15 Antibody, 25tests","description":"\u003cp\u003eGPR15, also known as BOB, is a G-protein coupled receptor with 7 transmembrane regions, that is present on the cell surface as an homotrimer. Its ligand, GPR15L, was recently identified. It acts as receptor for human immunodeficiency virus type 1 and 2. GPR15 is expressed by effector T cells and subsets of memory T cells, and is involved in the recruitment of proinflammatory CD4 + T cells responsible of the pathogenesis in colitis. It is upregulated on monocytes and neutrophils in the synovia of patients with RA.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human GPR15-transfected cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2894501 (BioLegend Cat. No. 373009) AB_2894501 (BioLegend Cat. No. 373010)\u003cbr\u003e\nStructure: G-protein coupled receptor with 7 transmembrane regions, present in the cell surface as homotrimer.\u003cbr\u003e\nDistribution: Effector and memory T cells.\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Nguyen LP, et al. 2015. Nat. Immunol. 16:207. 2. Kiene M, et al. 2014. PLoS One 9:e88195. 3. Cartwright A, et al. 2014. Cytokine. 67:53. 4. Kim SV, et al. 2013. Science. 340:1456. 5. Okamoto Y, et al. 2013. J. Biol. Chem. 288:9189.\u003cbr\u003e\nGene ID: 2838\u003cbr\u003e\nUniProt: View information about GPR15 on UniProt.org\u003cbr\u003e\nClone: SA302A10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BOB, Brother of Bonzo\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866291032233,"sku":"373009","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-373009","provider":"Iright","version":"1.0","type":"link"}