{"product_id":"biolegend-373402","title":"Biolegend, 373402, Purified anti-human CD18 Antibody, 100μg","description":"\u003cp\u003eCD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human peripheral blood lymphocytes\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The 1B4\/CD18 antibody was able to partially block the Ts1\/18 antibody, indicating the two anti-CD18 antibodies recognize distinct but overlapping epitopes.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Singer II, et al. 1993. J. Immunol. 150:2844.Seth R, et al. 1991. FEBS Lett. 282:193.\u003cbr\u003e\nRRID: AB_2650942 (BioLegend Cat. No. 373402)\u003cbr\u003e\nStructure: Integrin, type I transmembrane glycoprotein\u003cbr\u003e\nDistribution: Leukocytes\u003cbr\u003e\nFunction: Adhesion and signaling in hematopoietic cells\u003cbr\u003e\nInteraction: Associates with CD11a, CD11b, or CD11c\u003cbr\u003e\nLigand\/Receptor: ICAMs\u003cbr\u003e\nCell Type: Leukocytes, Tregs\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Hogg N, et al. 1999. J. Clin. Invest. 103:97. 2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175. 3. Springer TA. 1994. Cell 76:301.\u003cbr\u003e\nGene ID: 3689\u003cbr\u003e\nUniProt: View information about CD18 on UniProt.org\u003cbr\u003e\nClone: 1B4\/CD18\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin beta-2, integrin beta chain, beta 2\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860846399657,"sku":"373402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-373402","provider":"Iright","version":"1.0","type":"link"}