{"product_id":"biolegend-375014","title":"Biolegend, 375014, Brilliant Violet 421™ anti-human CD159c (NKG2C) Antibody, 100tests","description":"\u003cp\u003eCD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In humans, the NKG2C\/CD94 complex interacts with HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human NKG2C\/CD94-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication Notes: S19005E does not crossreact with mouse CD159c.\u003cbr\u003e\nRRID: AB_3675090 (BioLegend Cat. No. 375013) AB_3675090 (BioLegend Cat. No. 375014)\u003cbr\u003e\nStructure: Type II transmembrane proteins of the C-type lectin superfamily\u003cbr\u003e\nDistribution: NK cells, NKT cells, T cell subsets\u003cbr\u003e\nFunction: Activating NK cell receptor\u003cbr\u003e\nLigand\/Receptor: HLA-E\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immuno-Oncology, Immunology\u003cbr\u003e\nMolecular Family: Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Malisheni M, et al. 2017. Front Immunol. 8:863. Sáez-Borderías A, et al. 2009. J Immunol, 182:829. Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.\u003cbr\u003e\nGene ID: 3822\u003cbr\u003e\nUniProt: View information about CD159c on UniProt.org\u003cbr\u003e\nClone: S19005E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866258329769,"sku":"375014","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-375014","provider":"Iright","version":"1.0","type":"link"}