{"product_id":"biolegend-376908","title":"Biolegend, 376908, FITC anti-human TLR7 Antibody, 100tests","description":"\u003cp\u003eToll-like receptor (TLR) 7, also known as CD287 is a type 1 transmembrane protein, member of the TLR receptor family. TLR7 is expressed intracellularly in plasmacytoid dendritic cells, myeloid cells, and B lymphocytes and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR7 signals through MyD88, which leads to the activation and secretion of IFN-α\/β and other inflammatory cytokines.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Clone S18024F can be used for blocking R848-activated IL8 cytokine secretion (tested on 293XL\/TLR7 cell line) and for intracellular flow cytometry.\u003cbr\u003e\nRRID: AB_2922600 (BioLegend Cat. No. 376907) AB_2922600 (BioLegend Cat. No. 376908)\u003cbr\u003e\nStructure: Type 1 transmembrane protein, member of the Toll-like receptor (TLR) family\u003cbr\u003e\nDistribution: Expressed intracellularly in plasmacytoid dendritic cells, myeloid cells, and B lymphocytes, Monocytes\u003cbr\u003e\nFunction: Pattern recognition receptor that detects single-stranded RNA, induces proinflammatory cytokine production\u003cbr\u003e\nInteraction: B cells, Dendritic cells\u003cbr\u003e\nLigand\/Receptor: Single-stranded RNA\u003cbr\u003e\nCell Type: B cells, Dendritic cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Innate Immune Signaling\u003cbr\u003e\nGene ID: 51284\u003cbr\u003e\nUniProt: View information about TLR7 on UniProt.org\u003cbr\u003e\nClone: S18024F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Toll-like receptor (TLR) 7, CD287\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866254495913,"sku":"376908","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-376908","provider":"Iright","version":"1.0","type":"link"}