{"product_id":"biolegend-378402","title":"Biolegend, 378402, Purified anti-human TMPRSS2 Antibody, 100μg","description":"\u003cp\u003eTMPRSS2 is a membrane-anchored protein that belongs to the serine protease family and is involved in many physiological and pathological processes. TMPRSS2 participates in proteolytic cascades and is important in normal physiological function of the prostate. Autocleavage leads to secretion of the protease domain. TMPRSS2 is involved in extracellular matrix disruption and metastasis of prostate cancer cells and activates several substrates, including pro-hepatocyte growth factor\/HGF, the protease activated receptor-2\/F2RL1 or matriptase\/ST14. TMPRSS2 promotes uptake of SARS-CoV-1, MERS-CoV, and SARS-CoV-2 viral particles of by proteolytic cleavage of ACE2 receptor and cleavage of coronavirus spike glycoproteins.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: huTMPRSS2 transfectant\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P- Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2910437 (BioLegend Cat. No. 378402)\u003cbr\u003e\nStructure: Single-pass type II membrane protein\u003cbr\u003e\nDistribution: Cell membrane, activated by cleavage and secreted\u003cbr\u003e\nFunction: Hydrolase, protease, serine protease\u003cbr\u003e\nInteraction: ACE2, HGF, F2RL1, ST14\u003cbr\u003e\nCell Type: Epithelial cells, Platelets\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology, COVID-19\u003cbr\u003e\nMolecular Family: Proteases\u003cbr\u003e\nAntigen References: Hoffman M, et al. 2020. Cell. 181:271-280. Yu J, et al. 2010. Cancer Cell. 17:443-54. Shen LW, et al. 2017. Biochimie. 142:1-10.\u003cbr\u003e\nGene ID: 7113\u003cbr\u003e\nUniProt: View information about TMPRSS2 on UniProt.org\u003cbr\u003e\nClone: S20014A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transmembrane protease serine 2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866266914985,"sku":"378402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-378402","provider":"Iright","version":"1.0","type":"link"}