{"product_id":"biolegend-378703","title":"Biolegend, 378703, PE anti-human CD238\/KEL Recombinant Antibody, 25tests","description":"\u003cp\u003eQA20A42 recognizes human CD238 also known as the kell blood group antigen Kpbc, KELL and ECE3. CD238 is an approximately 115 kD type II transmembrane glycoprotein that is encoded by the KEL gene. CD238 is expressed on erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues, including testis, heart, brain and skeletal muscle. CD238 functions as a zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Decreased expression of CD238 is associated with the McLeod phenotype as a consequence of losing XK protein expression.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone QA20A42 can completely block the binding of positive clone to target cells.\u003cbr\u003e\nRRID: AB_2936750 (BioLegend Cat. No. 378703) AB_2936750 (BioLegend Cat. No. 378704)\u003cbr\u003e\nStructure: Type II transmembrane glycoprotein 93-115 kD\u003cbr\u003e\nDistribution: Erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues\u003cbr\u003e\nFunction: Zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Blood transfusions and also specific autoimmune diseases related to Kell antigen recognition.\u003cbr\u003e\nLigand\/Receptor: Laminin α5\u003cbr\u003e\nCell Type: Embryonic Stem Cells, Erythrocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Blood Group Markers, CD Molecules\u003cbr\u003e\nAntigen References: Daniels G. 2009. Hum Genet. 126:729-42. Denomme GA. 2015. Immunohematology. 31:14-9.\u003cbr\u003e\nGene ID: 3792\u003cbr\u003e\nUniProt: View information about CD238\/KEL on UniProt.org\u003cbr\u003e\nClone: QA20A42\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Kell blood group glycoprotein, Kell blood group antigen Kpbc, KELL and ECE3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866191548585,"sku":"378703","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-378703","provider":"Iright","version":"1.0","type":"link"}