{"product_id":"biolegend-378802","title":"Biolegend, 378802, Purified anti-human CD239\/B-CAM Recombinant Antibody, 100μg","description":"\u003cp\u003eQA20A43 recognizes human CD239, also known as Lutheran antigen or Basal Cell Adhesion Molecule (B-CAM). Human CD239 is a type I transmembrane glycoprotein that is encoded by B-CAM which belongs to the Ig gene superfamily. Full-length BCAM (CD239) is comprised of an extracellular region with two N-terminal V-type Ig-like domains followed by three C2-type Ig-like domains, a transmembrane region, and cytoplasmic domain of 59 amino acid residues. CD239 is expressed on erythrocytes in the peripheral blood and on the basal layer of vascular endothelial cells or some epithelial cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC – Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone QA20A43 can completely block the binding of positive clone to target cells.\u003cbr\u003e\nRRID: AB_2910443 (BioLegend Cat. No. 378802)\u003cbr\u003e\nStructure: ~85 kD single pass type I membrane glycoprotein\u003cbr\u003e\nDistribution: Erythrocytes in the peripheral blood and on the basal layer of vascular endothelial cells or some epithelial cells\u003cbr\u003e\nFunction: CD239 is upregulated upon malignant transformation of some cell types including those found in ovarian carcinomas and plays a role in epithelial cell cancer and in the vaso-occlusion of red blood cells in sickle cell disease.\u003cbr\u003e\nLigand\/Receptor: CD239 is a receptor for the extracellular matrix protein, laminin\u003cbr\u003e\nCell Type: Antigen-presenting cells, Endothelial cells, Epithelial cells, Erythrocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules, Soluble Receptors\u003cbr\u003e\nAntigen References: El Nemer W, et al. 1998. J Biol Chem. 273:16686-93. Parsons SF, et al. 1997. Blood. 89:4219-25.\u003cbr\u003e\nGene ID: 4059\u003cbr\u003e\nUniProt: View information about CD239\/B-CAM on UniProt.org\u003cbr\u003e\nClone: QA20A43\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lutheran antigen. Basal Cell Adhesion Molecule (B-CAM, Lutheran blood group). B-CAM cell surface glycoprotein\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866191679657,"sku":"378802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-378802","provider":"Iright","version":"1.0","type":"link"}