{"product_id":"biolegend-378902","title":"Biolegend, 378902, Purified anti-human TSPAN8 Antibody, 100μg","description":"\u003cp\u003eTetraspanin 8 (TSPAN8) is a member of the transmembrane IV superfamily.  It is a cell surface protein with four hydrophobic domains. Tetraspanins are constitutive components of exosomes and are involved in adhesion, motility, matrix modulation and cell fusion. TSPAN8 mediates signal transduction events that regulate cell development, activation, growth, and motility. It is expressed in gastric, colon, rectal, and pancreatic carcinomas. \u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: huTSPAN8 transfectant\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2910444 (BioLegend Cat. No. 378902)\u003cbr\u003e\nStructure: Multi-pass membrane protein\u003cbr\u003e\nDistribution: Cell membrane, lysosomes\u003cbr\u003e\nFunction: Tyrosine-based internalization, recruitment into endosomes\u003cbr\u003e\nInteraction: LIPR1, MEP1B, STX1-2, TIM23, S38A7\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: Szala S, et al. 1990. Proc Natl Acad Sci USA. 87:6833-7. Rana S, et al. 2011. Int J Biochem Cell Biol. 43:106-19. Nazarenko I, et al. 2010. Cancer Res. 70:1668-78. Berthier-Vergnes O, et al. 2011. Br J Cancer. 104:155-68.\u003cbr\u003e\nGene ID: 7103\u003cbr\u003e\nUniProt: View information about TSPAN8 on UniProt.org\u003cbr\u003e\nClone: S20010A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tetraspanin-8\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866264228009,"sku":"378902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-378902","provider":"Iright","version":"1.0","type":"link"}