{"product_id":"biolegend-379403","title":"Biolegend, 379403, PE anti-human IL-1RL1 (ST2) Antibody, 25tests","description":"\u003cp\u003eIL1RL1 is a member of the Toll-like receptor superfamily the receptor for Interleukin-33. It is a 556 amino acid single-pass type I membrane protein. ST2 exists in two forms as splice variants: a soluble form, which acts as a decoy receptor and sequesters free IL-33, and a membrane-bound form (ST2), which activates the MyD88\/NF-κB signaling pathway. Signaling through IL1RL1 drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells. IL-33 signaling is required for maintaining the suppressive function of regulatory T cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human IL-1RL1, AA19-328\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2922608 (BioLegend Cat. No. 379403) AB_2922608 (BioLegend Cat. No. 379404)\u003cbr\u003e\nStructure: Single-pass type I membrane protein\u003cbr\u003e\nDistribution: Th2 lymphocytes, mast cells, eosinophils, basophils, smooth muscle cells, endothelial cells\u003cbr\u003e\nFunction: Cytokine signaling\u003cbr\u003e\nInteraction: Signaling requires association of the coreceptor IL1RAP. Recruits MYD88, IRAK1, IRAK4, and TRAF6.\u003cbr\u003e\nLigand\/Receptor: IL-33\u003cbr\u003e\nCell Type: Basophils, Endothelial cells, Eosinophils, Lymphocytes, NK cells, Th2, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Schmitz J, et al. 2005. Immunity. 23: 479-490. Brint E, et al. 2004. Nat Immun. 5:373-379. Griesenauer B, et al. 2017. Front Immunol. 8:475.\u003cbr\u003e\nGene ID: 9173\u003cbr\u003e\nUniProt: View information about IL-1RL1 on UniProt.org\u003cbr\u003e\nClone: A16008J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-33R, ST2, IL-1RL1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864391733417,"sku":"379403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-379403","provider":"Iright","version":"1.0","type":"link"}