{"product_id":"biolegend-379905","title":"Biolegend, 379905, APC anti-human CD11b Recombinant Antibody, 25tests","description":"\u003cp\u003eCD11b (integrin alpha M subunit) is a type I transmembrane glycoprotein. CD11b combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M\/beta 2, also known as Mac-1 and complement receptor type 3 (CR3). Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen. CD11b is primarily expressed on granulocytes, monocytes\/macrophages, dendritic cells, NK cells, and subsets of T and B cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: The binding of clone QA20A58 can be completely blocked by reference clone. Other anti-hCD11b clone ICRF44 does not affect the binding of clone QA20A58 to target.\u003cbr\u003e\nRRID: AB_3068038 (BioLegend Cat. No. 379905) AB_3068038 (BioLegend Cat. No. 379906)\u003cbr\u003e\nStructure: Integrin family, associates with integrin β2 (CD18), 170 kD\u003cbr\u003e\nDistribution: Granulocytes, monocytes\/macrophages, dendritic cells, NK cells, subsets of T and B cells\u003cbr\u003e\nFunction: Adhesion, chemotaxis, phagocytosis, neutrophil activation\u003cbr\u003e\nLigand\/Receptor: ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Granulocytes, Neutrophils, NK cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. Springer TA. 1994. Cell. 76:301-14. Coxon A, et al. 1996. Immunity. 5:653-66.\u003cbr\u003e\nGene ID: 3684\u003cbr\u003e\nUniProt: View information about CD11b on UniProt.org\u003cbr\u003e\nClone: QA20A58\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: alpha-chain of C3bi receptor, alphaM, C3bi receptor, CD11b, gp155\/95, integrin a, M-chain, Mac-1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866192302249,"sku":"379905","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-379905","provider":"Iright","version":"1.0","type":"link"}