{"product_id":"biolegend-381804","title":"Biolegend, 381804, PE anti-human HLA-G Recombinant Antibody, 100tests","description":"\u003cp\u003eHLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A, B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expressed on trophoblast cells. Its expression is also found on thymic epithelial cells, cytokine-activated moncytes, macrophages\/dendritic cells during viral infection, and in various tumors. HLA-G exerts its inhibitory functions to regulate immune tolerance via interaction with inhibitory receptors ILT2 (CD85j), ILT4 (CD85d), and KIR2DL4 (CD158d), which is expressed on NK cells, T cells, monocytes, dendritic cells, and B cells. HLA-G is also able to bind CD8α\/α, which may mediate positive and\/or negative selection in the thymus.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone QA19A11 partially blocks the binding of reported clone MEMG\/9.\u003cbr\u003e\nRRID: AB_3106085 (BioLegend Cat. No. 381803) AB_3106085 (BioLegend Cat. No. 381804)\u003cbr\u003e\nStructure: Ig\u003cbr\u003e\nDistribution: Trophoblast cells, thymic epithelial cells, cytokine-activated moncytes, macrophages\/dendritic cells during viral infection, various tumors\u003cbr\u003e\nFunction: Inhibit NK and T cell-mediated cytolysis and T cell proliferation, induce apoptosis of activated CD8+ T cells, induce Th2 cytokine production\u003cbr\u003e\nInteraction: Dendritic cells, Epithelial cells, Macrophages, Monocytes\u003cbr\u003e\nLigand\/Receptor: ILT2 (CD85j), ILT4 (CD85d), KIR2DL4 (CD158d), CD8α\/α\u003cbr\u003e\nCell Type: Dendritic cells, Epithelial cells, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: Hunt JS, et al. 2005. FASEB J. 19:681. Carosella ED, et al. 2008. Blood. 111:4862.\u003cbr\u003e\nGene ID: 3135\u003cbr\u003e\nUniProt: View information about HLA-G on UniProt.org\u003cbr\u003e\nClone: QA19A11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866185715881,"sku":"381804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-381804","provider":"Iright","version":"1.0","type":"link"}