{"product_id":"biolegend-382111","title":"Biolegend, 382111, PE\/Dazzle™ 594 anti-human CD157 (BST-1) Antibody, 25tests","description":"\u003cp\u003eCD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a GPI-anchored glycoprotein. It is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. It is prevalently expressed by cells of the myelomonocytic lineage, and modulates adhesion of neutrophils and monocytes to the extracellular matrix. CD157 is expressed in 97% of primary acute myeloid leukemia samples, and is used as a marker for diagnosis of Paroxysmal Nocturnal Hemoglobinuria, a disease caused by intrinsic deficiency of GPI anchors.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: hCD157 stable transfectant followed by recombinant protein (aa29-293)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3068112 (BioLegend Cat. No. 382111) AB_3068112 (BioLegend Cat. No. 382112)\u003cbr\u003e\nStructure: GPI-anchored, ADP-ribosyl cyclase\u003cbr\u003e\nDistribution: Cell Membrane\u003cbr\u003e\nFunction: ADP-ribosyl cyclase activity. Fibronectin, fibrinogen, laminin-1 and type 1 collagen binding. Hydrolase, Transferase.\u003cbr\u003e\nInteraction: CD11b\/CD18, ECM components\u003cbr\u003e\nLigand\/Receptor: NAD, NADP\u003cbr\u003e\nCell Type: Antigen-presenting cells, Granulocytes, Monocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Proliferation and Viability, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Enzymes and Regulators, Innate Immune Signaling\u003cbr\u003e\nAntigen References: Ortolan E, et al. 2019. Immunology Letters. 205:59-64 Ferrero E, et al. 2017. Sci Rep. 7: 15923. Kaisho T, et al. 1994. Proc Natl Acad Sci USA. 91:5325-9. Morone S, et al. 2014. J Biol Chem. 289:15588-601.\u003cbr\u003e\nGene ID: 683\u003cbr\u003e\nUniProt: View information about CD157 on UniProt.org\u003cbr\u003e\nClone: W21007F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BST1\u003cbr\u003e\nIsotype: Rat IgG2a, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866426429609,"sku":"382111","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-382111","provider":"Iright","version":"1.0","type":"link"}