{"product_id":"biolegend-384402","title":"Biolegend, 384402, Purified anti-human CD45 Recombinant Antibody, 100μg","description":"\u003cp\u003eCD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2927952 (BioLegend Cat. No. 384402)\u003cbr\u003e\nStructure: Type I transmembrane protein, 180 – 240 kD (multiple isoforms)\u003cbr\u003e\nDistribution: Hematopoietic cells, except circulating erythrocytes or platelets\u003cbr\u003e\nFunction: Tyrosine phosphatases, signaling\u003cbr\u003e\nCell Type: B cells, Granulocytes, Leukocytes, Lymphocytes, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Thomas M. 1989. Annu Rev Immunol. 7:339-69. Trowbridge I, et al. 1994. Annu Rev Immunol. 12:85-116.\u003cbr\u003e\nGene ID: 5788\u003cbr\u003e\nUniProt: View information about CD45 on UniProt.org\u003cbr\u003e\nClone: QA21A24\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD45, Leukocyte Common Antigen (LCA), T200\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866195153065,"sku":"384402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-384402","provider":"Iright","version":"1.0","type":"link"}