{"product_id":"biolegend-387804","title":"Biolegend, 387804, PE anti-human CD226 (DNAM-1) Antibody, 100tests","description":"\u003cp\u003eDNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes\/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-set. The ligands for CD226 are the poliovirus receptor (CD155) and its family member nectin-2 (CD112), which are broadly expressed on epithelial, endothelial and neuronal cells. CD226 is physically associated with LFA-1 in NK cells and activated T cells, and involved in LFA-1-mediated signaling.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human DNAM-1 Transfected Cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3068124 (BioLegend Cat. No. 387803)\u003cbr\u003e\nStructure: Ig domain containing adhesion molecule\u003cbr\u003e\nDistribution: Peripheral blood T cells, NK cells, monocytes\/macrophages, platelets and megakaryocytes and a subset of B cells\u003cbr\u003e\nFunction: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell\u003cbr\u003e\nInteraction: Interacts with LFA-1\u003cbr\u003e\nLigand\/Receptor: PVR (CD155) and Nectin-2 (CD112)\u003cbr\u003e\nCell Type: B cells, Macrophages, Megakaryocytes, Monocytes, NK cells, Platelets, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Shibuya A, et al. 1996. Immunity. 4:573-81. Tahara-Hanaoka S, et al. 2004. Int Immunol. 16:533-8. Pende D, et al. 2005. Mol. Immunol. 42:463-9.\u003cbr\u003e\nGene ID: 10666\u003cbr\u003e\nUniProt: View information about CD226 on UniProt.org\u003cbr\u003e\nClone: W21097F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DNAM-1, PTA1, TLiSA1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866429771945,"sku":"387804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-387804","provider":"Iright","version":"1.0","type":"link"}