{"product_id":"biolegend-391902","title":"Biolegend, 391902, Purified anti-human GPR56 Antibody, 100μg","description":"\u003cp\u003eGPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids.  GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8 + , CD4 + , and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human GPR56 extracellular domain, complete Freund’s adjuvant, incomplete Freund’s adjuvant\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested Blocking, Direct ELISA, IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: blocking the cell migration (1).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ohta S, et al. 2015. Biol. Pharm. Bull. 38:594.\u003cbr\u003e\nRRID: AB_2687290 (BioLegend Cat. No. 391902)\u003cbr\u003e\nStructure: Contains seven transmembrane domains and a mucin-like domain in the N-terminal region.\u003cbr\u003e\nDistribution: T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart.\u003cbr\u003e\nFunction: May be involved in immune cell migration, cancer cell growth metastasis, and neuron development.\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nAntigen References: 1. Peng YM, et al. 2011. J. Leuko. Biol. 90:735. 2. Shashidhar S, et al. 2005. Oncogene 24:1673. 3. Piao X, et al. 2004. Science 303:2033. 4. Liu M, et al. 1999. Genomics 55:296.\u003cbr\u003e\nGene ID: 9289\u003cbr\u003e\nUniProt: View information about GPR56 on UniProt.org\u003cbr\u003e\nClone: 4C3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TM7XN1, ADGRG1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862413332649,"sku":"391902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-391902","provider":"Iright","version":"1.0","type":"link"}