{"product_id":"biolegend-392506","title":"Biolegend, 392506, PE anti-human CD19 Antibody, 100tests","description":"\u003cp\u003eCD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR co-receptor.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Chronic Lymphocytic Leukemia (CLL) cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone 4G7 partially blocks anti-human CD19 clones HIB19 and SJ25C1 staining based on in-house testing\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Cabezudo E, et al. 1999. Haematologica. 84:413-8 Van Zelm MC et al. 2010. J Clin Invest. 120:1265-74\u003cbr\u003e\nProduct Citations: Fatehi Hassanabad A, et al. 2022. JTCVS Open. 12:118. PubMed Griffith AA, et al. 2022. J Proteome Res. 21:395. PubMed Morris V, et al. 2022. Cell Rep. 39:110752. PubMed Lu Y, et al. 2020. Cell. 180(6):1081-1097. PubMed Qi S, et al. 2021. Biol Sex Differ. 12:66. PubMed Li H, et al. 2020. Mol Ther Methods Clin Dev. 1.436111111. PubMed Fang F, et al. 2022. JCI Insight. 7:. PubMed Manzano-Muñoz A, et al. 2021. Front Cell Dev Biol. 9:695225. PubMed Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed Lu Y, et al. 2020. STAR Protoc. 1:100040. PubMed\u003cbr\u003e\nRRID: AB_2750096 (BioLegend Cat. No. 392505) AB_2750097 (BioLegend Cat. No. 392506)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 95 kD\u003cbr\u003e\nDistribution: Normal and malignant B lymphocytes\u003cbr\u003e\nFunction: B cell activation and differentiation\u003cbr\u003e\nLigand\/Receptor: Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor\u003cbr\u003e\nCell Type: B cells, Lymphocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Tedder T, et al. 1994. Immunol. Today 15:437. Bradbury L, et al. 1993. J. Immunol. 151:2915.\u003cbr\u003e\nGene ID: 930\u003cbr\u003e\nUniProt: View information about CD19 on UniProt.org\u003cbr\u003e\nClone: 4G7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: B4, CVID3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862416806057,"sku":"392506","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-392506","provider":"Iright","version":"1.0","type":"link"}