{"product_id":"biolegend-392915","title":"Biolegend, 392915, Brilliant Violet 421™ anti-human CD66b Antibody, 25tests","description":"\u003cp\u003eCD66b is a 95-100 kD glycosylphosphatidylinositol (GPI)-linked protein also known as CD67, CGM6, and NCA-95. CD66b is a member of the immunoglobulin superfamily, carcinoembryonic antigen (CEA)-like subfamily. CD66b, expressed on granulocytes, has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CD66c.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant soluble human CEACAM8-Fc produced in HEK293 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. For immunohistochemistry, a concentration range of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Singer, et al. 2014. PLoS One. 9(4):e94106. PMID: 24743304 Klaile, et al. 2013. Respir Res. 14:85. PMID 23941132\u003cbr\u003e\nProduct Citations: Kanan MK, et al. 2023. JCI Insight. . PubMed Miralda I, et al. 2023. J Allergy Clin Immunol. 711:152. PubMed Horn KJ, et al. 2024. J Leukoc Biol. 4:115. PubMed Pettinella F, et al. 2024. Cell Rep Med. 101380:5. PubMed Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed\u003cbr\u003e\nRRID: AB_2888722 (BioLegend Cat. No. 392915) AB_2888722 (BioLegend Cat. No. 392916)\u003cbr\u003e\nStructure: Ig superfamily, CEA antigen group, GPI-linked glycoprotein\u003cbr\u003e\nDistribution: Granulocytes\u003cbr\u003e\nFunction: Cell adhesion, neutrophil activation\u003cbr\u003e\nLigand\/Receptor: CD66c\u003cbr\u003e\nCell Type: Granulocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Kuijpers T, et al. 1993. J Immunol. 151:4934. Kuroki M, et al. 1992. J Leuk Biol. 52:551.\u003cbr\u003e\nGene ID: 1088\u003cbr\u003e\nUniProt: View information about CD66b on UniProt.org\u003cbr\u003e\nClone: 6\/40c\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CEACAM8, CD67, CGM6, NCA-95\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862465695913,"sku":"392915","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-392915","provider":"Iright","version":"1.0","type":"link"}