{"product_id":"biolegend-393208","title":"Biolegend, 393208, PE\/Cyanine7 anti-human CD27 Recombinant Antibody, 100tests","description":"\u003cp\u003eCD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70, and plays a role in costimulation of T cell activation and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK\/JNK activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone QA17A18 does not block clones 0323, M-T271, or LG.3A10, indicating a unique epitope.\u003cbr\u003e\nRRID: AB_2750092 (BioLegend Cat. No. 393207) AB_2750093 (BioLegend Cat. No. 393208)\u003cbr\u003e\nStructure: TNF-R superfamily, type I transmembrane glycoprotein.\u003cbr\u003e\nDistribution: Medullary thymocytes, T and B cell subsets, NK cells.\u003cbr\u003e\nLigand\/Receptor: CD70\u003cbr\u003e\nCell Type: B cells, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, TCRs\u003cbr\u003e\nAntigen References: Knapp W, et al. 1989. Immunol. Today 10:253-8 Schlossman S, et al. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. Hintzen R, et al. 1994. Immunol. Today 15:307. Agematsu K, et al. 1995. J. Immunol. 154:3627.\u003cbr\u003e\nGene ID: 939\u003cbr\u003e\nUniProt: View information about CD27 on UniProt.org\u003cbr\u003e\nClone: QA17A18\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: S152, T14, TNFRSF7\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866176475305,"sku":"393208","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-393208","provider":"Iright","version":"1.0","type":"link"}