{"product_id":"biolegend-393407","title":"Biolegend, 393407, PE\/Cyanine7 anti-human CD45 Recombinant Antibody, 25tests","description":"\u003cp\u003eCD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone QA17A19 does not block clones 2D1 and HI30 indicating a unique epitope.\u003cbr\u003e\nRRID: AB_2750084 (BioLegend Cat. No. 393407) AB_2750085 (BioLegend Cat. No. 393408)\u003cbr\u003e\nStructure: Type I transmembrane protein, 180 - 240 kD (multiple isoforms)\u003cbr\u003e\nDistribution: Hematopoietic cells, except circulating erythrocytes or platelets.\u003cbr\u003e\nFunction: Tyrosine phosphatases, signaling, co-stimulation (co-inhibition), TCR and BCR mediated activation.\u003cbr\u003e\nLigand\/Receptor: Galectin-1, CD2, CD3, and CD4.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Neutrophils\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, TCRs\u003cbr\u003e\nAntigen References: Thomas M. 1989. Annu. Rev. Immunol. 7:339. Trowbridge I, Thomas ML. 1994. Annu. Rev. Immunol. 12:85.\u003cbr\u003e\nGene ID: 5788\u003cbr\u003e\nUniProt: View information about CD45 on UniProt.org\u003cbr\u003e\nClone: QA17A19\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leukocyte Common Antigen, LCA, T200\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866177097897,"sku":"393407","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-393407","provider":"Iright","version":"1.0","type":"link"}