{"product_id":"biolegend-394510","title":"Biolegend, 394510, Alexa Fluor® 488 anti-human CD285 (TLR5) Antibody, 100tests","description":"\u003cp\u003eCD285, also known as TLR5, is a 98 kD pattern recognition receptor that binds to bacterial flagellin. It is expressed on dendritic cells, classical monocytes and mucosal epithelial cells and is involved in activation of TLR5 induced NF-κB mediated activation of inflammatory-related target genes. Mutations in the TLR5 gene have been linked with susceptibility to systemic lupus erythematosus and Legionnaire’s disease.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TLR5 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nRRID: AB_2892462 (BioLegend Cat. No. 394509) AB_2892462 (BioLegend Cat. No. 394510)\u003cbr\u003e\nStructure: Type 1 transmembrane protein, 98 kD\u003cbr\u003e\nDistribution: Neutrophils, classical monocytes, dendritic cells, mucosal epithelium\u003cbr\u003e\nFunction: Interacts with MyD88 and TRAF6 leading to NF-κB activation and production of cytokines.\u003cbr\u003e\nLigand\/Receptor: flagellin\u003cbr\u003e\nCell Type: Dendritic cells, Epithelial cells, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: Hayashi F, et al. 2001. Nature. 410:1099 Gewirtz AT, et al. 2001. J Immunol. 167:1882 Smith KD, et al. 2002. Curr Top Microbiol Immunol. 270:93 Bambou JC, et al. 2004. J Biol Chem. 279:42984 Sebastiani G, et al. 2000. Genomics. 64:230 Muzio M, et al. 2000. Biochem Soc Trans. 28:563\u003cbr\u003e\nGene ID: 7100\u003cbr\u003e\nUniProt: View information about CD285 on UniProt.org\u003cbr\u003e\nClone: S16021I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SLE1, TIL3, SLEB1, MELIOS, CD285\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866227921065,"sku":"394510","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-394510","provider":"Iright","version":"1.0","type":"link"}