{"product_id":"biolegend-395408","title":"Biolegend, 395408, Biotin anti-human TSPAN33 (BAAM) Antibody, 100μg","description":"\u003cp\u003eTSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TSPAN33-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2801045 (BioLegend Cat. No. 395408)\u003cbr\u003e\nStructure: Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).\u003cbr\u003e\nDistribution: Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney\u003cbr\u003e\nFunction: Modulates TLR-induced proinflammatory gene expression\u003cbr\u003e\nCell Type: B cells, Macrophages\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Immuno-Oncology, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23. Ruiz-García A, et al. 2016. J Immunol. 197:3371. Luu VP, et al. 2013. Clin Immunol. 149:388. Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95. Maecker HT et al. 1997. FASEB J. 11:428.\u003cbr\u003e\nGene ID: 340348\u003cbr\u003e\nUniProt: View information about TSPAN33 on UniProt.org\u003cbr\u003e\nClone: SA17RN1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tetraspanin-33, BAAM, Penumbra, PEN\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866283331753,"sku":"395408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-395408","provider":"Iright","version":"1.0","type":"link"}