{"product_id":"biolegend-406501","title":"Biolegend, 406501, Purified anti-mouse IgM Antibody, 50μg","description":"\u003cp\u003eIgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on the majority of mature B cells.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse Ig cocktail\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The IgM antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested ELISA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The RMM-1 antibody reacts with both soluble and membrane immunoglobulin M in all tested mouse haplotypes (Igh-a and b). It does not react with other isotypes. Some formats of the RMM-1 antibody may be used as primary or secondary reagent for immunofluorescent staining or ELISA analysis.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tertilt C, et al. 2009. Infect. Immun. 77:3044. (ELISA) PubMed\u003cbr\u003e\nProduct Citations: Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed Wang W, et al. 2020. Cell Rep. 107936:32. PubMed Mouat IC, et al. 2021. Elife. 10:. PubMed Sun L, et al. 2021. Cell Reports. 35(9):109188. PubMed Plzakova L, et al. 2015. PLoS One. 10: 0132571. PubMed Qiu Z, et al. 2022. Cancer Discov. 12:502. PubMed Englezou PC, et al. 2018. Mol Ther Nucleic Acids. 12:118. PubMed Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed Lin J, et al. 2017. Nat Commun. . 10.1038\/s41467-017-01477-5. PubMed Maity P, et al. 2015. Sci Signal. 8: ra93. PubMed Tertilt C, et al. 2009. Infect Immun. 77:3044. PubMed\u003cbr\u003e\nRRID: AB_315051 (BioLegend Cat. No. 406501) AB_315052 (BioLegend Cat. No. 406502)\u003cbr\u003e\nStructure: Ig family\u003cbr\u003e\nDistribution: B cells\u003cbr\u003e\nFunction: B cell differentiation, humoral immune response; cross-linking surface IgM induces apoptosis\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nGene ID: 16019\u003cbr\u003e\nUniProt: View information about IgM on UniProt.org\u003cbr\u003e\nClone: RMM-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Immunoglobulin M\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866201706665,"sku":"406501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-406501","provider":"Iright","version":"1.0","type":"link"}