{"product_id":"biolegend-513004","title":"Biolegend, 513004, PE anti-human IL-21 Antibody, 100tests","description":"\u003cp\u003eInterleukin 21 (IL-21) is a potent immunomodulatory cytokine primarily produced by NKT cells and CD4 + T cells, particularly the inflammatory Th17 subset. It exerts pleiotropic effects on both innate and adaptive immune responses. These include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. IL-21 also has proapoptotic effects on B cells and NK cells. Recent studies have shown that IL-21 functions as an autocrine cytokine, strongly inducing Th17 differentiation and suppressing Foxp3 expression, making it a potential therapeutic target for treating cancer and inflammatory diseases.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full length human IL-21\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Korniotis S, et al. 2022. J Cell Sci. 135:. PubMed Zheng B, et al. 2019. J Leukoc Biol. 987:106. PubMed Wijesinghe A, et al. 2020. J Biomed Sci. 27:50:00. PubMed Grandclaudon M, et al. 2019. Cell. 179:432. PubMed Mudd PA, et al. 2022. Cell. 185:603. PubMed Fang F, et al. 2021. Cell Rep. 37:109981. PubMed Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed\u003cbr\u003e\nRRID: AB_1877230 (BioLegend Cat. No. 513003) AB_2249025 (BioLegend Cat. No. 513004)\u003cbr\u003e\nDistribution: Th17\u003cbr\u003e\nFunction: Immunomodulation\u003cbr\u003e\nCell Sources: NK-T cells and T cells\u003cbr\u003e\nCell Targets: Cytotoxic T cells (CTL) and Natural Killer (NK) cells that can destroy malignant or infected cells\u003cbr\u003e\nReceptors: IL-21R\u003cbr\u003e\nCell Type: Th17\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Nurieva R. 2007. Nature 448:416. 2. Parrish-Novak J, et al. 2002. J. Leukocyte Biol. 72:856. 3. Dumoutier L, et al. 2000. Proc. Natl. Acad. Sci. USA 97:10144. 4. Asao H, et al. 2001. J. Immunol. 167:1. 5. Parrish-Novak J, et al. 2000. Nature 408:57.\u003cbr\u003e\nGene ID: 59067\u003cbr\u003e\nUniProt: View information about IL-21 on UniProt.org\u003cbr\u003e\nClone: 3A3-N2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin 21\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862385217705,"sku":"513004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-513004","provider":"Iright","version":"1.0","type":"link"}