{"product_id":"biolegend-514401","title":"Biolegend, 514401, Purified anti-mouse IL-25 (IL-17E) Antibody, 50μg","description":"\u003cp\u003eIL-25 (IL-17E) is a member of the IL-17 family of proinflammatory cytokines which include at least six members including IL-17A (IL-17), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: IL-25\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ELISA - Quality tested Neut - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Neutralization: The Ultra-LEAF™ purified antibody (Endotoxin \u0026lt;0.01 EU\/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-25 bioactivity (Cat. No. 514417).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Angkasekwinai P, et al. 2007. J. Exp Med. 204:1509.\u003cbr\u003e\nRRID: AB_2043954 (BioLegend Cat. No. 514401)\u003cbr\u003e\nStructure: Cytokine; 19 kD\u003cbr\u003e\nBioactivity: Induce proinflammatory responses, promote the expression of the prototypical Th2 genes\u003cbr\u003e\nCell Sources: Activated Th2 cells, bone marrow-derived mast cells, and alveolar macrophages\u003cbr\u003e\nCell Targets: IL-17RB mRNA transcripts are abundantly expressed in the kidney and liver and at lower levels in the testes, brain, small intestine, and other organs.\u003cbr\u003e\nReceptors: IL-17BR (EVI27, IL17Rh1)\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Fort MM, et al. 2001. Immunity 15:985. 2. Lee J, et al. 2001. J. Biol Chem. 276:1660. 3. Hurst SD, et al. 2002. J. Immunol. 169:443. 4. Kleinschel MA, et al. 2007. J. Exp. Med. 204:161.\u003cbr\u003e\nGene ID: 140806\u003cbr\u003e\nUniProt: View information about IL-25 on UniProt.org\u003cbr\u003e\nClone: 35B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-17E\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862379843753,"sku":"514401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-514401","provider":"Iright","version":"1.0","type":"link"}