{"product_id":"biolegend-515408","title":"Biolegend, 515408, Pacific Blue™ anti-human\/mouse Granzyme B Antibody, 100tests","description":"\u003cp\u003eGranzyme B is a 32 kD serine protease, also known as granzyme-2, serine protease B, CCP1, Asp-ase, and CTLA-1. Granzyme B is abundantly stored in the granules of cytotoxic T lymphocytes and NK cells. Low level of expression has been reported in granulocytes, B cells, and activated dendritic cells. Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nReported Reactivity: Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Pacific Blue™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Wever PC, et al. 1998. Immunology. 93:383 Arens R, et al. 2004. J. Exp. Med. 199:1595 Lima M, et al. 2003. Am. J. Pathol. 163:763 Wiede F, et al. 2014. J Autoimmun. 53:105. PubMed Baker GF, et al. 2014. Cancer Res. 74:5079. PubMed Nacer A, et al. 2014. PLoS Pathog. 10:1004528. PubMed Sharma SK, et al. 2015. J Immunol. 194:5529. PubMed\u003cbr\u003e\nProduct Citations: Moderzynski K, et al. 2016. PLoS Negl Trop Dis. . PubMed Harsha Krovi S, et al. 2020. Nat Commun. 4.790277778. PubMed Chan LC, et al. 2019. J Clin Invest. 129:3324. PubMed Murray C, et al. 2022. Int J Mol Sci. 23:. PubMed Konjar S, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202144119. PubMed Xiong H, et al. 2023. EBioMedicine. 90:104507. PubMed Liu J, et al. 2023. Nat Commun. 14:2806. PubMed Garnier L, et al. 2022. Sci Adv. 8:eabl5162. PubMed Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed Campisi L, et al. 2022. Nature. 606:945. PubMed Krishnamurty AT, et al. 2022. Nature. 611:148. PubMed Huseni MA, et al. 2023. Cell Rep Med. 4:100878. PubMed Dean JW 2023. Cell Reports. 42(1):111963. PubMed Drijvers JM, et al. 2021. Cancer Immunol Res. 9:184. PubMed Reticker-Flynn NE, et al. 2022. Cell. 185:1924. PubMed Wang L, et al. 2019. Cell Rep. 29:1848. PubMed Xu W et al. 2019. Immunity. 50(4):1054-1068 . PubMed Remy-Ziller C, et al. 2017. Hum Vaccin Immunother. 10.1080\/21645515.2017.1373921. PubMed Marquardt I, et al. 2022. Front Microbiol. 12:752549. PubMed Boal-Carvalho I, et al. 2020. EMBO Rep. 21:e50421. PubMed Cheng L, et al. 2021. Cancer Immunol Immunother. Online ahead of print. PubMed Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed Myers JA, et al. 2022. JCI Insight. :. PubMed Böttcher JP, et al. 2018. Cell. 172:1022. PubMed Tan X, et al. 2021. Front Oncol. 11:768222. PubMed Narasimhan PB, et al. 2018. PLoS Negl Trop Dis. 12:e0006404. PubMed Reyes RM, et al. 2021. Oncoimmunology. 10:2006529. PubMed Verma A, et al. 2021. Cell Rep. 37:109942. PubMed Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed Snell LM, et al. 2018. Immunity. 49:678. PubMed Uceda-Castro R, et al. 2022. Cell Rep Med. 3:100821. PubMed Khan A, et al. 2015. J Virol. 89: 6619 - 6632. PubMed Moderzynski K, et al. 2017. PLoS Negl Trop Dis. 11(2):e0005404. PubMed Fan Z, et al. 2020. EMBO Mol Med. 12:e11571. PubMed Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed Barsoumian HB, et al. 2020. J Immunother Cancer. 8:00. PubMed Ren Y, et al. 2022. J Immunother Cancer. 10:. PubMed Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed Li C, et al. 2020. Immunity. 52(1):201-202. PubMed OConnor RA, et al. 2021. OncoImmunology. 10(1):1940675. PubMed Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed LM S, et al. 2016. Cell Rep. 16(12): 3286-96. PubMed Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed Koelwyn GJ, et al. 2020. Nat Med. 1452:26. PubMed Di Mitri D, et al. 2019. Cell Rep. 28:2156. PubMed Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed Burel J, et al. 2016. PLoS Negl Trop Dis. 10:e0005031. PubMed Younes AI, et al. 2021. Transl Oncol. 14:100983. PubMed Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed Li E, et al. 2021. Front Immunol. 12:667177. PubMed Georg P, et al. 2022. Cell. 185:493. PubMed Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed Wells AC et al. 2017. eLife. 6 pii: e26398. PubMed Spolski R et al. 2019. Elife. 8 pii: e45501. PubMed Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed Dai X, et al. 2021. Molecular Cell. 81(11):2317-2331.e6. PubMed Glodde N et al. 2017. Immunity. 47(4):789-802 . PubMed Peterfalvi A, et al. 2021. Int J Environ Res Public Health. 18:. PubMed Burger ML, et al. 2021. Cell. 184:4996. PubMed Laczkó D, et al. 2020. Immunity. 53:724. PubMed Wolf Y, et al. 2019. Cell. 179:219. PubMed Kuranda K, et al. 2018. J Clin Invest. 128:5267. PubMed Yang X, et al. 2021. Sci Rep. 11:13482. PubMed\u003cbr\u003e\nRRID: AB_2562195 (BioLegend Cat. No. 515407) AB_2562196 (BioLegend Cat. No. 515408)\u003cbr\u003e\nStructure: 32 kD serine protease\u003cbr\u003e\nDistribution: Cytotoxic T-cells and NK cells, low on granulocytes, B cells and activated dendritic cells\u003cbr\u003e\nFunction: Induction of cell death and apoptosis\u003cbr\u003e\nLigand\/Receptor: Mannose-6-phosphate receptor\u003cbr\u003e\nCell Type: B cells, Dendritic cells, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Proteases\u003cbr\u003e\nAntigen References: 1. Estebanez-Perpina E, et al. 2000. Biol Chem. 381:1203 2. Griffiths GM. And S. Isaaz, et al. 1993. J. Cell Biol. 120:885 3. Spaeny-Dekking EH, et al. 1998. J. Immunol. 160:3610 4. Wagner C, et al. 2008. Mol. Immunol. 45:1761\u003cbr\u003e\nGene ID: 300214939171528\u003cbr\u003e\nUniProt: View information about Granzyme B on UniProt.org\u003cbr\u003e\nClone: GB11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Granzyme-2, serine protease B, CCP1, Asp-ase, CTLA-1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866453201065,"sku":"515408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-515408","provider":"Iright","version":"1.0","type":"link"}