{"product_id":"biolegend-517605","title":"Biolegend, 517605, Biotin anti-human IL-2 Antibody, 50μg","description":"\u003cp\u003eIL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation. Additionally, IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Polyclonal\u003cbr\u003e\nHost Species: Goat\u003cbr\u003e\nImmunogen: Recombinant human IL-2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: ELISA Detection - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA detection antibody, a concentration range of 0.25-1.0 µg\/ml is recommended. To obtain a linear standard curve, serial dilutions of human IL-2 protein ranging from 500 to 7.8 pg\/ml are recommended for each ELISA plate when paired with MQ1-17H12 (Cat. No. 500302). It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: ELISA Detection: The biotinylated Poly5176 antibody is useful as a detection antibody for a sandwich ELISA assay, when used in conjunction with purified MQ1-17H12 (Cat. No. 500302) antibody as the capture antibody.Note: For testing human IL-2 in serum or plasma, BioLegend's LEGEND MAX™ Kits (Cat. No. 431807 \u0026amp; 431808) are specially developed and recommended.\u003cbr\u003e\nProduct Citations: Wang X, et al. 2022. Cancers (Basel). 14:. PubMed Yan J, et al. 2020. Cell Rep. 107820:31. PubMed\u003cbr\u003e\nRRID: AB_2564274 (BioLegend Cat. No. 517605)\u003cbr\u003e\nStructure: Cytokine; 15.4 kD (Mammalian)\u003cbr\u003e\nBioactivity: Proliferation of T lymphocytes, B cells, anti-inflammatory, hematopoiesis, tumor surveillance\u003cbr\u003e\nCell Sources: T cells\u003cbr\u003e\nCell Targets: T cells, B cells, NK cells, LAK cells, monocytes, macrophages, oligodendrocytes\u003cbr\u003e\nReceptors: High affinity heterotrimer of IL-2Ra\/b\/g, intermediate affinity homodimer IL-2Ra (CD25; p55; Tac) and heterodimer IL-2Rb (CD122)\/g; g-subunit (CD132) in common with IL-4R, IL-7R, IL-13R, IL-15R\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego. 2. Taniguchi T, et al. 1993. Cell 73:5. 3. Nistico G. 1993. Prog. Neurobiol. 40:463. 4. Waldmann T, et al. 1993. Ann. NY Acad. Sci. 685:603.\u003cbr\u003e\nRegulation: Upregulated by NFAT; downregulated by TCF-8, CIF (colostrums inhibitory factor)\u003cbr\u003e\nGene ID: 3558\u003cbr\u003e\nUniProt: View information about IL-2 on UniProt.org\u003cbr\u003e\nClone: Poly5176\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-2, T cell growth factor (TCGF), Killer cell helper factor (KHF), Macrophage-activating factor for cytotoxicity I (MAF-C I)\u003cbr\u003e\nIsotype: Goat Polyclonal IgG\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866164514985,"sku":"517605","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-517605","provider":"Iright","version":"1.0","type":"link"}