{"product_id":"biolegend-519303","title":"Biolegend, 519303, Biotin anti-mouse IL-34 Antibody, 50μg","description":"\u003cp\u003eIL-34 is a homodimeric glycoprotein which contains 241 amino acids. IL-34 is expressed in the heart, brain, lung, liver, kidney, thymus, spleen, and other organs. It specifically binds to CD115\/M-CSF receptor (CSF-1 receptor or c-Fms) and activates ERK1\/2 phosphorylation. The function of IL-34 overlaps with CSF-1 to regulate myeloid lineage differentiation, proliferation, and survival.  Elevated levels of IL-34 are seen in the plasma of rheumatoid arthritis patients, but can be decreased in response to therapy. IL-34 levels are also increased in the serum of cancer patients and associated with poor prognosis.  Mouse IL-34 shares 71% sequence identity with human IL-34 on the amino acid level.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Polyclonal\u003cbr\u003e\nHost Species: Goat\u003cbr\u003e\nImmunogen: Recombinant mouse IL-34\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: ELISA Detection - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA assay. A concentration of 0.5 µg\/ml detection antibody was utilized to generate the example standard curve. It is recommended that the end-user titrate each lot of reagents for optimal performance.\u003cbr\u003e\nApplication Notes: ELISA Detection: To measure mouse IL-34, this antibody can be used as a detection antibody in sandwich ELISA format, and paired with the LEAF™ purified C054-35 antibody (Cat. No. 147201) as the capture antibody. Recombinant Mouse IL-34 (ELISA Std.) (Cat. No. 577609) can be used as the protein standard.Note: For testing mouse IL-34 in serum, plasma or cell culture supernatant, BioLegend's LEGEND MAX™ ELISA Kits (Cat. No. 439107 \u0026amp; 439108) are specially developed and recommended.\u003cbr\u003e\nRRID: AB_2561419 (BioLegend Cat. No. 519303)\u003cbr\u003e\nStructure: Homodimer\u003cbr\u003e\nDistribution: Expressed in different tissues, including spleen, heart, brain, lung, liver, kidney, thymus, testes, ovary, small intestine, prostate, and colon\u003cbr\u003e\nFunction: Regulates myeloid lineage differentiation, proliferation, and survival\u003cbr\u003e\nInteraction: Macrophages, monocytes, and myeloid cells\u003cbr\u003e\nLigand\/Receptor: CD115\/M-CSF receptor (CSF-1 receptor or c-Fms)\u003cbr\u003e\nCell Type: Dendritic cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Lin H, et al. 2008. Sciences 320:807. 2. Chihara T, et al. 2010. Cell Death Differ. 17:1917. 3. Wei S, et al. 2010. J. Leuko. Biol. 88:495. 4. Eda H, et al. 2011. Rheumatol 31:1525. 5. Covaleda L, et al. 2010. Virology 397:217.\u003cbr\u003e\nGene ID: 76527\u003cbr\u003e\nUniProt: View information about IL-34 on UniProt.org\u003cbr\u003e\nClone: Poly5193\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL34, Interleukin 34, C16orf77\u003cbr\u003e\nIsotype: Goat Polyclonal Ig\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866164580521,"sku":"519303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-519303","provider":"Iright","version":"1.0","type":"link"}