{"product_id":"biolegend-526002","title":"Biolegend, 526002, Purified anti-human M-CSF Antibody, 500μg","description":"\u003cp\u003eM-CSF is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer. M-CSF is released by fibroblasts, breast cancer cell lines, alveolar macrophages, stromal bone marrow cells, endothelial cells, and mesenchymal cells. It binds CD14 + monocytes and promotes the survival\/proliferation of human peripheral blood monocytes. In addition, M-CSF enhances inducible monocyte functions including phagocytic activity, microbial killing, cytotoxicity for tumor cells as well as synthesis of inflammatory cytokines such as IL-1, TNF-α, and IFN-γ in monocytes. M-CSF induces RANKL production in mature human osteoclasts and, consequently, this makes M-CSF a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF production in human monocytes and human tumor cells. High levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human M-CSF\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2563444 (BioLegend Cat. No. 526002)\u003cbr\u003e\nStructure: Three isoforms with 256-554 amino acids, predicted molecular weight of approximately 30-70 kD.\u003cbr\u003e\nDistribution: Cell membrane; single-pass membrane protein. Processed macrophage colony-stimulating factor 1: secreted, extracellular space.\u003cbr\u003e\nFunction: Controls the production, differentiation, and function of macrophages.\u003cbr\u003e\nInteraction: Homodimer or heterodimer, disulfide-linked. Interacts with CSF1R.\u003cbr\u003e\nLigand\/Receptor: M-CSFR or CSF1R (CD115).\u003cbr\u003e\nBiology Area: Cell Biology, Cell Proliferation and Viability, Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines, Growth Factors\u003cbr\u003e\nAntigen References: 1. Kawasaki ES, et al. 1985. Science 230:291. 2. Wei S, et al. 2010. J. Leuko. Biol. 88:495. 3. Hodge JM, et al. 2011. PloS One 6:e21462. 4. Morandi A, et al. 2011. PloS One 6:e27450. 5. Erblich B, et al. 2011. PloS One 6:e26317. 6. MacDonald KP, et al. 2010. Blood 116:3955.\u003cbr\u003e\nGene ID: 1435\u003cbr\u003e\nUniProt: View information about M-CSF on UniProt.org\u003cbr\u003e\nClone: L1617F1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CSF1, CSF-1, MCSF\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866119000233,"sku":"526002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-526002","provider":"Iright","version":"1.0","type":"link"}