{"product_id":"biolegend-531304","title":"Biolegend, 531304, Biotin anti-human IL-1α Antibody, 50μg","description":"\u003cp\u003eIL-1 refers to two proteins, IL-1α and IL-1β which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1α is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses. Recombinant human IL-1α is an 18.0 kD protein containing 159 amino acids.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Polyclonal\u003cbr\u003e\nHost Species: Goat\u003cbr\u003e\nImmunogen: Recombinant human IL-1α\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: ELISA Detection - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA. For ELISA detection applications, a concentration of 0.25 µg\/mL is recommended. To obtain a linear standard curve, serial dilutions of IL-1α recombinant protein ranging from 200 to 1.56 pg\/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance.\u003cbr\u003e\nApplication Notes: The biotinylated Poly5313 antibody is useful as a detection antibody for a sandwich ELISA assay, when used in conjunction with purified 343-3B3-14 (Cat. No. 500104) antibody as the capture antibody. Note: For human IL-1a in cell culture supernatant, serum, plasma or other bodily fluids, BioLegend's LEGEND MAX™ Kits (Cat. No. 434907 \u0026amp; 434908) are specially developed and recommended.\u003cbr\u003e\nRRID: AB_2686960 (BioLegend Cat. No. 531304)\u003cbr\u003e\nStructure: Cytokine\u003cbr\u003e\nDistribution: Monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglias, gliomas, keratinocyte\u003cbr\u003e\nFunction: Upregulated by TNF-α, IFN-α, IFN-β, IFN-γ, bacterial endotoxins, viruses, mitogens, antigens; downregulated by IL-6, lipoproteins, lipids, and α2-macroglobulin\u003cbr\u003e\nInteraction: B cells, T cells, monocytes, dendritic cells\u003cbr\u003e\nLigand\/Receptor: Type I IL-1R (CDw121a), Type II IL-1R (CDw121b)\u003cbr\u003e\nCell Type: Astrocytes, B cells, Dendritic cells, Endothelial cells, Fibroblasts, Langerhans cells, Macrophages, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego. 2. Bomford R, et al. Eds. 1989. Interleukin-1 inflammation and disease. Elsevier New York. 3. Brazel D, et al. 1991. Biotechnol. Ther. 2:241. 4. Dinarello C et al. 1996. Blood 87:2095.\u003cbr\u003e\nGene ID: 3552\u003cbr\u003e\nUniProt: View information about IL-1alpha on UniProt.org\u003cbr\u003e\nClone: Poly5313\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-1α, Lymphocyte-activating factor (LAF), Endogenous pyrogen (EP), Leukocyte endogenous mediator (LEM), Mononuclear cell factor (MCF\/MNCF)(il-1a,il1a)\u003cbr\u003e\nIsotype: Goat Polyclonal Ig\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866166186153,"sku":"531304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-531304","provider":"Iright","version":"1.0","type":"link"}