{"product_id":"biolegend-602652","title":"Biolegend, 602652, Purified anti-MAPK14 Antibody, 100μg","description":"\u003cp\u003eMAPK14 is a member of the p38 MAPK family of serine\/threonine-specific kinases. MAPK14 plays a critical role in signal transduction, and upon activation, modulates the activity of diverse signaling families, such as the TNF, TGF, and EGFR pathways, and regulates diverse behaviors including inflammation, stress response, cell cycle, apoptosis, transcription and translation. MAPK14 is important for organogenesis, participating in the development of the heart and blood vessels.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human MAPK14 protein fragments\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 2.5 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For ICC, we recommend 4% PFA fixation followed by permeabilization with ice cold methanol. We do not recommend 4% PFA fixation followed by permeabilization with 0.5% Triton-X, or fixation\/permeabilization with ice cold methanol alone.\u003cbr\u003e\nRRID: AB_2910477 (BioLegend Cat. No. 602651) AB_2910477 (BioLegend Cat. No. 602652)\u003cbr\u003e\nStructure: MAPK14 is a 360 amino-acid protein with a predicted molecular weight of 41 kD.\u003cbr\u003e\nDistribution: MAPK14 is widely expressed in the cytoplasm and nucleus of most tissues.\u003cbr\u003e\nFunction: MAPK14 is a serine\/threonine kinase.\u003cbr\u003e\nInteraction: MAPK14 phosphorylates myriad targets including transcription factors, other kinases, enzymes, and histone proteins.\u003cbr\u003e\nBiology Area: Signal Transduction\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Canovas B, Nebreda A. 2021. Nat Rev Mol Cell Biol. 22:346-366.\u003cbr\u003e\nGene ID: 1432\u003cbr\u003e\nUniProt: View information about MAPK14 on UniProt.org\u003cbr\u003e\nClone: 5A1-C5-F11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Mitogen-Activated Protein Kinase 14 (MAPK14), cytokine suppressive anti-inflammatory Drug Binding Protein, PRKM14, PRKM15, p38, SAPK2A\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864150266025,"sku":"602652","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-602652","provider":"Iright","version":"1.0","type":"link"}