{"product_id":"biolegend-603452","title":"Biolegend, 603452, Purified anti-Maf Antibody, 100μg","description":"\u003cp\u003eTranscription factor Maf (Maf) is a transcription factor encoded by the MAF gene. In a complex as a homo- or hetero-dimer, Maf acts as a transcriptional activator and repressor with diverse functions. For example, Maf plays numerous roles in the immune system by regulating IL-4 expression and modulating T-cell apoptosis, and is also a critical regulator of glucagon production in pancreatic alpha cells. Additionally, Maf plays a role in the development of multiple tissues, including the eye, bone, and blood vessels. Mutations in Maf are known to cause congenital and juvenile cataracts.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant N-terminus fragment of human Maf\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC, ICFC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg\/mL is recommended. For intracellular flow cytometric staining, the suggested use of this reagent is 0.03 - 0.05 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone has been tested and does not work for IHC-P. For ICC application, paraformaldehyde plus Triton-X and paraformaldehyde plus methanol fix\/perm methods are recommended. The use of methanol only as fix\/perm is not suitable for this antibody. For ICFC application, Cyto-Fast™ Fix\/Perm Buffer Set (Cat. No. 426803) is recommended.\u003cbr\u003e\nRRID: AB_2910482 (BioLegend Cat. No. 603451) AB_2910482 (BioLegend Cat. No. 603452)\u003cbr\u003e\nStructure: Maf is a 373 amino-acid protein with a predicted molecular weight of 38.5 kD.\u003cbr\u003e\nDistribution: Nucleus\u003cbr\u003e\nFunction: Transcription factor\u003cbr\u003e\nInteraction: Maf has been shown to interact with CREBBP, EP300, MYB and SOX9.\u003cbr\u003e\nCell Type: Endothelial cells, Osteoblasts, T cells, Th2\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Death, Transcription Factors\u003cbr\u003e\nAntigen References: Imbratta C, et al. 2020. Front Immunol. 11:206. Zhang C and Guo ZM. 2015. Diabetes Metab Res Rev. 31:773-8.\u003cbr\u003e\nGene ID: 4094\u003cbr\u003e\nUniProt: View information about Maf on UniProt.org\u003cbr\u003e\nClone: W18010A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transcription factor Maf, Proto-oncogene c-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog, T Lymphocyte C-Maf Long Form\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866328387753,"sku":"603452","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-603452","provider":"Iright","version":"1.0","type":"link"}