{"product_id":"biolegend-605556","title":"Biolegend, 605556, Alexa Fluor® 647 anti-Jun Phospho (Ser73) Antibody, 100tests","description":"\u003cp\u003ec-Jun is the first oncogenic transcription factor ever discovered. It heterodimerizes with members of the Fos protein family, such as c-Fos, to form the AP-1 transcription factor complex, exhibiting both activating and repressive functions depending on the interacting partner and promoter sequence context. c-Jun is required for cell cycle progression, and is protective against DNA damage, such as that resulting from ultraviolet light exposure. c-Jun is also overexpressed in many cancers including lung, breast and vulvar cancer, and is a target for anti-cancer therapies. Phosphorylation of c-Jun at serine 63 and 73 is activational, and mediated by the MAPK signaling cascade.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide of human c-Jun phosphorylated at Ser73\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3097471 (BioLegend Cat. No. 605555) AB_3097471 (BioLegend Cat. No. 605556)\u003cbr\u003e\nStructure: c-Jun is a 331 amino acid protein with a predicted molecular weight of 35.7 kD.\u003cbr\u003e\nDistribution: c-Jun is primarily expressed in the nucleus\u003cbr\u003e\nFunction: Transcription factor\u003cbr\u003e\nInteraction: c-Jun forms the AP-1 transcription factor complex by heterodimerizing with proteins of the Fos family\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology, Cell Cycle\/DNA Replication, DNA Repair\/Replication, Transcription Factors\u003cbr\u003e\nMolecular Family: Phospho-Proteins\u003cbr\u003e\nAntigen References: Pulverer B, et al. 1991. Nature. 353:670-4. Vogt P. 2001.Oncogene. 20:2365-77 . Brennan A, et al. 2020. J Exp Clin Cancer Res. 39:184.\u003cbr\u003e\nGene ID: 3725\u003cbr\u003e\nUniProt: View information about Jun Phospho Ser73 on UniProt.org\u003cbr\u003e\nClone: A19012A\/R\/C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transcription factor Jun, activator protein 1 (AP1), Proto-oncogene c-Jun, transcription factor AP-1 subunit Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866065850537,"sku":"605556","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-605556","provider":"Iright","version":"1.0","type":"link"}