{"product_id":"biolegend-605751","title":"Biolegend, 605751, Purified anti-NSE Antibody, 25μg","description":"\u003cp\u003eMammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers. Expression of these isozymes can be cell-type and development-specific. This gene encodes gamma enolase (enolase 2) and is expressed in mature neurons and cells of neuronal origin. The alpha\/alpha homodimers are expressed in embryo and in most adult tissues. The alpha\/beta heterodimers and the beta\/beta homodimers are found in striated muscle, and the alpha\/gamma heterodimers and the gamma\/gamma homodimers are expressed in neurons. Neuron specific enolase is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung cancer.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human NSE\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2924615 (BioLegend Cat. No. 605751) AB_2924615 (BioLegend Cat. No. 605752)\u003cbr\u003e\nStructure: Gamma enolase is a 434 amino acid protein with a molecular mass of 47 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Nervous and musculoskeletal systems. Cellular distribution: Secreted, cytosol, plasma membrane, cytoskeleton, and nucleus.\u003cbr\u003e\nFunction: Gamma enolase has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. It binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.\u003cbr\u003e\nCell Type: Mature Neurons, Neurons\u003cbr\u003e\nBiology Area: Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: Murray GI, et al. 1993. J Clin Pathol. 46:993-6. Duncan ME, et al. 1992. J immunol Methods. 151:2227-36.\u003cbr\u003e\nGene ID: 2026\u003cbr\u003e\nUniProt: View information about NSE on UniProt.org\u003cbr\u003e\nClone: A18254F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gamma-enolase, neural enolase, neuron-specific enolase (NSE), enolase 2 (ENO2), 2-phospho-D-glycerate hydrolyase\u003cbr\u003e\nIsotype: Mouse IgG2b, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866064965801,"sku":"605751","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-605751","provider":"Iright","version":"1.0","type":"link"}