{"product_id":"biolegend-612155","title":"Biolegend, 612155, Biotin anti-human YKL-40 (CHI3L1) Antibody, 50μg","description":"\u003cp\u003eYKL-40, also known as CHI3L1 (Chitinase-3-like protein 1) or cartilage glycoprotein-39 (GP-39) is secreted by chondrocytes, synoviocytes, endothelial cells, smooth muscle cells and immune cells. YKL-40 plays a major role in different physiological processes including cell proliferation, tissue remodeling, angiogenesis, and apoptosis. Elevated serum levels of YKL-40 are linked to the pathogenesis and prognosis of several inflammatory reactions and autoimmune diseases, such as cancer, rheumatoid arthritis, liver cirrhosis, diabetes, and inflammatory bowel disease. Higher YKL-40 levels in cerebral spinal fluid are a known biomarker of brain inflammation and have a potential prognostic utility as a disease-specific marker in neurodegenerative disorders.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Recombinant CHI3L1 Protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A19120F) could function as a detection antibody when paired with purified anti-human YKL-40 (CHI3L1) antibody (Cat No. TBD) (clone W19120B) as the capture antibody and using Recombinant Human Chitnase 3-like 1 (carrier-free) (Cat No. 56802 and 568706) protein as the assay standard. For assay development flexibility purposes, this product is provided as a biotin format.\u003cbr\u003e\nRRID: AB_3720582 (BioLegend Cat. No. 612155)\u003cbr\u003e\nStructure: Monomer\u003cbr\u003e\nDistribution: Dendritic cells, Macrophages\u003cbr\u003e\nInteraction: Macrophages, Neutrophils, T cells\u003cbr\u003e\nLigand\/Receptor: IL-13Rα2, Syndecan-1\u003cbr\u003e\nCell Type: Endothelial cells, Granulocytes, Leukemia, Macrophages, Neurons\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Motility\/Cytoskeleton\/Structure, Cell Proliferation and Viability\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nGene ID: 1116\u003cbr\u003e\nUniProt: View information about YKL-40 on UniProt.org\u003cbr\u003e\nClone: A19120F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Chitnase-3-like protein 1, CHIL3L1, YKL-40, Cartilage glycoprotein 39, CGP-39, GP-39\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866067128489,"sku":"612155","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-612155","provider":"Iright","version":"1.0","type":"link"}