{"product_id":"biolegend-614002","title":"Biolegend, 614002, Purified anti-GATA2 Antibody, 100μg","description":"\u003cp\u003eGATA2 is a member of the GATA transription factor family. Mutations in GATA2 lead to impaired development and differentiation of hematopoietic  lineages, including dendritic cells, monocytes, B cells, and natural killer cells. Over the course of differentiation, GATA2 activates expression of the functionally distinct GATA1; promoter-occupied GATA2 is replaced\/exhanged at certain promoters with the GATA1 transcription factor, a process known as the GATA switch.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant partial human GATA2 protein corresponding to amino acids 1-250\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICFC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg\/mL. For intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810661 (BioLegend Cat. No. 614001) AB_2810662 (BioLegend Cat. No. 614002)\u003cbr\u003e\nStructure: GATA2 is a 480 amino acid protein with a predicted molecular weight of 51 kD.\u003cbr\u003e\nDistribution: Widely expressed\/nucleus\u003cbr\u003e\nFunction: Transcriptional activator\/Regulates developmental processes in hematopoietic cells\u003cbr\u003e\nCell Type: Lymphocytes\u003cbr\u003e\nBiology Area: Cell Biology, Stem Cells, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Orkin SH. 1992. Blood. 80: 575. Bresnick EH, et al. 2010. J. Biol. Chem. 285: 31087. Collin M, et al. 2011. Nat. Rev. Immunol. 11: 575. Doré LC, et al. 2012. Blood. 119: 3724.\u003cbr\u003e\nGene ID: 2624\u003cbr\u003e\nUniProt: View information about GATA2 on UniProt.org\u003cbr\u003e\nClone: W17242A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GATA Binding Protein 2, IMD21, NFE1B, DCML\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866328191145,"sku":"614002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-614002","provider":"Iright","version":"1.0","type":"link"}