{"product_id":"biolegend-615102","title":"Biolegend, 615102, Purified anti-RelB Antibody, 100μg","description":"\u003cp\u003eThe Nuclear Factor kappa-light chain-enhancer of activated B cell, or NF- κB, is a transcriptional complex that plays a critical role in inducing expression of genes involved in inflammation, stress responses, cell growth, and apoptosis. The functional NF- κB complex can be comprised of homo- or heterodimeric units of Rel-like\/homology domain containing proteins, including RelA, RelB, cRel, p50 and p52. RelB, which preferentially forms heterodimers with p50 and p52, is associated with non-canonical NF- κB signaling activation. This branch of NF- κB signaling is characterized by the NF-κB-inducing kinase (NIK)-linked processing of p100 instead of degradation of IκBα. Non-canonical NF-κB signaling is crucial for B-cell survival and maturation, and overexpression of RelB is associated with lymphoid malignancies and colorectal tumorigenesis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human RelB protein corresponding to amino acid residues 69-308\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.125 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone may produce a ~65 kD non-speccific band by WB when used at higher concentrations.This clone does not recognize mouse RelB.\u003cbr\u003e\nRRID: AB_2814454 (BioLegend Cat. No. 615101) AB_2814455 (BioLegend Cat. No. 615102)\u003cbr\u003e\nStructure: RelB is a 579 amino acid protein with a predicted molecular weight of 62 kD.\u003cbr\u003e\nDistribution: Ubiquitously expressed; nuclear and cytosolic localization.\u003cbr\u003e\nFunction: Transcriptonal regulator\u003cbr\u003e\nCell Type: Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Transcription Factors\u003cbr\u003e\nAntigen References: Beg AA, et al. 1992. Genes Dev. 6: 1899 Lernbecher T, et al. 1993. Nature. 365: 767. Lernbecher T, et al. 1994. EMBO J. 13:4060. Sun SC. 2011. Cell Res. 21: 71 Tao Y, et al. 2018. Ongogene. 37:5887\u003cbr\u003e\nGene ID: 5971\u003cbr\u003e\nUniProt: View information about RelB on UniProt.org\u003cbr\u003e\nClone: W16195A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IREL, IMD53\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866306695337,"sku":"615102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-615102","provider":"Iright","version":"1.0","type":"link"}