{"product_id":"biolegend-616601","title":"Biolegend, 616601, Purified anti-TGM2 Antibody, 25μg","description":"\u003cp\u003eTransglutaminase 2 (TGM2) is a multifunctional enzyme required for diverse cellular processes, including cell death, differentiaton, apoptosis, and cell migration. TGM2 catalyzes the crosslinking through calcium-activated transamidation of available glutamine and lysine residues on substrate proteins. TGM2 also has GTPase and ATPase activity; transamidation activity is allosterically inhibited by guanine nucleotide binding. It is essential for cancer stem cell survival and is a chemotherapy resistance factor.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial human recombinant human TGM2 protein corresponding to amino acids 1-250.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone was tested for ICC using PFA-fixed A431 cells permeabilized with Triton X-100 or methanol. Staining in the incorrect subcellular compartment was observed using each method; we therefore do not recommend this clone for ICC. This clone failed to immunoprecipitate TGM2 during PD testing.\u003cbr\u003e\nRRID: AB_2810665 (BioLegend Cat. No. 616601) AB_2810666 (BioLegend Cat. No. 616602)\u003cbr\u003e\nStructure: TGM2 is a 687 amino acid protein with a predicted molecular weight of 77 kD.\u003cbr\u003e\nDistribution: Tissue enriched\/cytosol localization\u003cbr\u003e\nFunction: Post translational modification, GTPase activity.\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Structure\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nGene ID: 7052\u003cbr\u003e\nUniProt: View information about TGM2 on UniProt.org\u003cbr\u003e\nClone: W17122A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase, Protein-Glutamine Gamma-Glutamyltransferase 2, Transglutaminase C, Transglutaminase H, Tissue Transglutaminase, Transglutaminase 2\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866313248937,"sku":"616601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-616601","provider":"Iright","version":"1.0","type":"link"}