{"product_id":"biolegend-617601","title":"Biolegend, 617601, Purified anti-PDPK1 Antibody, 25μg","description":"\u003cp\u003e3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1) is serine\/threonine kinase that plays a central role in diverse cellular pathways. It functions by phosphorylating and activating members of the AGC family of serine kinases, including Akt1, Protein Kinases A and C, and p70 ribosomal protein S6 kinase. Loss or reduction of PDPK1 in the thymus results in defective T-cell differentiation and proliferative expansion.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human PDPK1 protein corresponding to amino acid residues 411-556\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone is predicted to recognize rat PDPK1 due to high sequence conservation between the immunizing protein and the rat homolog.This clone is predicted to recognize PDPK1 isoforms 1-4 due to the presence of the immunizing sequence in each isoform.This clone failed ICC and IP testing.\u003cbr\u003e\nRRID: AB_2810673 (BioLegend Cat. No. 617601) AB_2810674 (BioLegend Cat. No. 617602)\u003cbr\u003e\nStructure: PDPK1 is a 556 amino acid protein with a predicted molecular weight of 63 kDa. Four PDPK1 isoforms exist ranging in size from 48-63 kD.\u003cbr\u003e\nDistribution: Peripheral plasma membrane protein\/ubiquitously expressed\u003cbr\u003e\nFunction: Regulator of insulin, PKC, Akt1, and SMAD signal tranduction\u003cbr\u003e\nBiology Area: Cell Biology\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Le Good JA, et al. 1998. Science. 281:2042. Dong LQ, et al. 2000. Proc. Natl. Acad. Sci. 97:5089. Hinton HJ, et al. 2004. Nat. Immunol. 5:539.\u003cbr\u003e\nGene ID: 5170\u003cbr\u003e\nUniProt: View information about PDPK1 on UniProt.org\u003cbr\u003e\nClone: W17215A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 3-Phosphoinositide-Dependent Protein Kinase 1, PDK1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866315608233,"sku":"617601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-617601","provider":"Iright","version":"1.0","type":"link"}