{"product_id":"biolegend-620252","title":"Biolegend, 620252, Purified anti-human CCL5 (RANTES) Antibody, 100μg","description":"\u003cp\u003eRANTES is a CC chemokine and directs the migration of leukocytes in immune and inflammatory responses. Increased CCL5\/RANTES expression has been associated with a wide range of inflammatory disorders and pathologies. This cytokine has been associated as well with the induction or promotion of cancer (prostate and breast). In the latter situation, RANTES can be angiogenic and also increase the metastatic potential of cancer cells by encouraging cellular migration to sites of its production. CCL5\/RANTES also inhibits HIV-1 entry and infection by competing with the virus for CCR5 binding.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Recombinant CCL5 Protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A19042E) could function as a capture antibody when paired with biotin anti-human CCL5 (RANTES) (Cat. No. 519703) (clone Poly5197) as the detection antibody and using Recombinant Human CCL5 (RANTES) (carrier-free) protein (Cat. Nos. 580202, 580204, and 580206) as the assay standard.\u003cbr\u003e\nRRID: AB_3675164 (BioLegend Cat. No. 620252)\u003cbr\u003e\nDistribution: RANTES\/CCL5 is secreted by lymphocytes, macrophages, eosinophils, platelets, and fibroblasts. RANTES is expressed by hepatocytes, sinusoidal endothelial cells and biliary epithelium during chronic hepatitis C.\u003cbr\u003e\nFunction: RANTES can promote IL-2 and IL-5 expression in human T cells, and the expression of IL-6 and IL-8 in fibroblasts from patients with RA. RANTES modulates the LPS-induced IL-6 and TNFα in peripheral blood monocytes; this modulation is through the induction of IL-10 by RANTES.\u003cbr\u003e\nInteraction: RANTES\/CCL5 is chemoattractant for memory and activated T cells, monocytes, dendritic cells, eosinophils, NK cells, mast cells, and basophils.\u003cbr\u003e\nLigand\/Receptor: CCL5 binds to CCR1, CCR3 and CCR5 receptors. In addition, CCL5 binds to CCR9; nevertheless, it does not induce calcium flux and therefore no chemotactic response.\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Proteases\u003cbr\u003e\nAntigen References: Schall, et al. 1990. Nature. 347:669-71. Cocchi F, et al. 1995. Science. 270:1811-5. Shahrara S, et al. 2006. J Immunology. 177:5077-87. Larrubia JR, et al. 2008. World J. Gastroenterol. 14:7149-59. Gleissner CA, et al. 2008. Arterioscler Thromb. Vasc. Biol. 28:1920-7.\u003cbr\u003e\nGene ID: 6352\u003cbr\u003e\nUniProt: View information about CCL5 on UniProt.org\u003cbr\u003e\nClone: A19042E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SIS-delta, T-cell specific protein p288, beta-chemokine RANTES, regulated upon activation, normally T-expressed, and presumably secreted, small inducible cytokine A5\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866066440361,"sku":"620252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-620252","provider":"Iright","version":"1.0","type":"link"}