{"product_id":"biolegend-621951","title":"Biolegend, 621951, Purified anti-PPP1CA Antibody, 25μg","description":"\u003cp\u003eProtein phosphatase 1 catalytic subunit alpha (PPP1CA) is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine\/threonine-specific protein phosphatase involved in the regulation of various cellular processes, such as cell division, glycogen metabolism, muscle contraction, protein synthesis, regulation of membrane receptors and channels, and HIV-1 virus transcription. PP1 has been shown to dephosphorylate RB and CDC25 during mitosis. Cell cycle-dependent phosphorylation at Thr320 of PPP1CA by CDC2 kinase inhibits PPP1CA activity. The studies in human and mice indicate that PP1 is an important regulator of cardiac function, and also show that PP1 suppresses learning and memory in mice.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: A synthetic peptide of human PPP1CA\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.125 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The clone cross-reacts with mouse and rat in western blotting (WB). For immunocytochemistry (ICC), we recommend to use 4% PFA fixation followed by permeabilization with 0.5% Triton X-100 or ice cold-methanol. This product is not recommended for use in immunohistochemistry (IHC).\u003cbr\u003e\nRRID: AB_3097497 (BioLegend Cat. No. 621951) AB_3097497 (BioLegend Cat. No. 621952)\u003cbr\u003e\nStructure: PPP1CA protein is a 330 amino acid protein with a predicted molecular weight of 38 kD\u003cbr\u003e\nDistribution: Upregulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis\u003cbr\u003e\nInteraction: FOXP3, CENPA, ATG16L1, TNS1, SAXO4, PPP1R21, PPP1R26, PPP1R27, PPP1R35, PPP1R36, PPP1R37, SH3RF2, ELFN1 and ELFN2\u003cbr\u003e\nCell Type: Neurons, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Cell Cycle\/DNA Replication, Cell Proliferation and Viability, Neuroscience, Protein Synthesis\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Rubin E, et al.1998. Front Biosci. 3:D1209-19. Durfee T, et al. 1993. Genes Dev. 7:555-69. Izumi T, et al. 1992. Mol Biol Cell. 3:927-39. Kwon YG, et al. 1997. PNAS. 94:2168-73. Carr AN, et al. 2002. Mol Cell Biol. 22:4124-35. Genoux D, et al. 2002. Nature. 418:970-5.\u003cbr\u003e\nGene ID: 5499\u003cbr\u003e\nUniProt: View information about PPP1CA on UniProt.org\u003cbr\u003e\nClone: W22109B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PP1A, PP-1A, PPP1A, PP1alpha, PP1α\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866433376425,"sku":"621951","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-621951","provider":"Iright","version":"1.0","type":"link"}