{"product_id":"biolegend-623001","title":"Biolegend, 623001, Purified anti-Gelsolin Antibody, 25μg","description":"\u003cp\u003eGelsolin (GSN) is a calcium-regulated protein that serves actin filament assembly and disassembly and regulates cytoskeletal actin organization. GSN caps the plus end of the actin-filament  to block monomer exchange, consequently, regulating filament length near the plasma membrane. Further, it contributes to cell movement and cell morphology. Four different isoforms of the molecule have been described that are produce via alternative splicing and initiation, including a soluble form. GSN is associated with a variety of diseases such as inflammation, cancer and amyloidosis.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial human recombinant Gelsolin protein (amino acids 239-503)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2814478 (BioLegend Cat. No. 623001) AB_2814479 (BioLegend Cat. No. 623002)\u003cbr\u003e\nStructure: GSN is a 782 amino acid protein with a predicted molecular weight of 86 kD\u003cbr\u003e\nDistribution: Actin Filaments\u003cbr\u003e\nFunction: Functions in assembly and disassembly of actin filaments.\u003cbr\u003e\nBiology Area: Cell Biology, Cell Motility\/Cytoskeleton\/Structure\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Janmey, P.A. and Stossel, T.P., 1987. Nature. 325:362 Burtnick LD, et al. 1997. Cell. 90:661.\u003cbr\u003e\nGene ID: 2934\u003cbr\u003e\nUniProt: View information about Gelsolin on UniProt.org\u003cbr\u003e\nClone: W18073A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GSN, Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866332680361,"sku":"623001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-623001","provider":"Iright","version":"1.0","type":"link"}