{"product_id":"biolegend-629302","title":"Biolegend, 629302, Purified anti-Elongin B Antibody, 100μg","description":"\u003cp\u003eElongin B (also known as RNA polymerase II transcription factor SIII p18 subunit and transcription elongation factor B polypeptide 2) is a member of the UbH family containing a ubiquitin-like domain. Elongin functions as a subunit of a general transcription elongation factor that increases RNA polymerase II transcription elongation past template-encoded arresting sites in the nucleus. The Elongin BC complex acts as adaptor to link Elongin A, VHL, WSB1 or SOCS1 with a module of CUL2 or CUL5 and RBX1 to form E3 ubiquitin ligases. Clone 10C4 recognizes the human elongin B protein and is useful for Western blotting.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length recombinant protein\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg\/ml.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Sato Y, et al. 2009. PLoS One. 5:e1000530. PubMed\u003cbr\u003e\nRRID: AB_2201267 (BioLegend Cat. No. 629302)\u003cbr\u003e\nStructure: UbH family, ubiquitin-like domain, heterotrimer; Human Elongin B has two isoforms with predicted MW of 13kD and 18kD\u003cbr\u003e\nDistribution: Nuclear\u003cbr\u003e\nFunction: Regulatory subunit of a general transcription elongation factor that increases RNA polymerase II transcription elongation past template-encoded arresting sites\u003cbr\u003e\nInteraction: Elongin BC complex acts as adaptor to link Elongin A, VHL, WSB1 or SOCS1 with a module of CUL2 or CUL5 and RBX1 to form E3 ubiquitin ligases\u003cbr\u003e\nBiology Area: Cell Biology, DNA Repair\/Replication, Transcription Factors, Ubiquitin\/Protein Degradation\u003cbr\u003e\nAntigen References: 1. Duan D, et al. 1995. Science. 269:1402. 2. Stebbins C, et al. 1999. Science. 284:455. 3. Brower C, et al. 2002. P. Natl. Acad. Sci. USA 99:10353. 4. DeRenzo C, et al. 2003. Nature. 424:685.\u003cbr\u003e\nGene ID: 6923\u003cbr\u003e\nUniProt: View information about Elongin B on UniProt.org\u003cbr\u003e\nClone: 10C4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: RNA polymerase II transcription factor SIII p18 subunit, transcription elongation factor B polypeptide 2, TCEB2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860779061417,"sku":"629302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-629302","provider":"Iright","version":"1.0","type":"link"}