{"product_id":"biolegend-634601","title":"Biolegend, 634601, Purified anti-hnRNPK Antibody, 25μg","description":"\u003cp\u003ehnRNP K (Heterogeneous nuclear ribonucleoprotein K) is a pre-mRNA binding protein and a component of hnRNP complexes providing substrate for pre-mRNA processing before becoming translatable mRNAs in cytoplasm. This protein containing KH domains and is ubiquitously expressed in the cytoplasm and the nucleus with a predicted molecular weight approximately 51 kD. hnRNP K expression and function are increased by epidermal growth factor (EGF). hnRNP K acts as transcriptional regulator and functions in nucleocytoplasmic shuttling, and is modified by phosphorylation (PKC δ, c-Src) and acetylation. Clone F45P9C7 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, rabbit and chicken hnRNP K.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Ovalbumin-conjugated synthetic Peptide SVKQYSGKFF\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg\/ml.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 µg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Carpenter B, et al. 2006. Br J Cancer. 95:921. PubMed Carpenter B, et al. 2007. Br J Cancer. 97:574. PubMed Alnabulsi A, et al. 2009. Methods of cancer diagnosis, therapy and diagnosis. 4:25.\u003cbr\u003e\nProduct Citations: Carpenter B, et al. 2006. Br J Cancer. 95:921. PubMed Roychoudhury P, Chaudhuri K 2007. Br J Cancer. 97:574. PubMed\u003cbr\u003e\nRRID: AB_2120365 (BioLegend Cat. No. 634601) AB_2120361 (BioLegend Cat. No. 634602)\u003cbr\u003e\nStructure: Heterogenous nuclear ribonucleoprotein family, KH domains; 51 kD\u003cbr\u003e\nDistribution: Ubiquitously expressed cytoplasmic and nuclear protein\u003cbr\u003e\nFunction: Pre-mRNA binding protein, component of hnRNP complexes providing substrate for pre-mRNA processing before becoming translatable mRNAs in cytoplasm. Acts as transcriptional regulator and functions in nucleocytoplasmic shuttling\u003cbr\u003e\nInteraction: Interacts with Csk, NCK2, Vav1, ITK, CEBP β, c-Src, Fyn, Lyn, Hepatitis virus core protein\u003cbr\u003e\nModification: Phosphorylation (PKC δ, c-Src), Acetylation, Methylation\u003cbr\u003e\nBiology Area: Cell Biology, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Matunis MJ, et al. 1992. Mol. Cell. Biol. 12:164. 2. Dejgaard K, et al. 1994. J. Mol. Biol. 236:33. 3. Mandal M, et al. 2001. J. Biol. Chem. 276:9699\u003cbr\u003e\nRegulation: Epidermal growth factor (EGF) can increase expression and function\u003cbr\u003e\nGene ID: 3190\u003cbr\u003e\nUniProt: View information about hnRNPK on UniProt.org\u003cbr\u003e\nClone: F45P9C7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Heterogeneous nuclear ribonucleoprotein K, DC-stretch binding protein, Transformation upregulated protein (TUNP), hnRNP K, hnRNP-K\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863988261033,"sku":"634601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-634601","provider":"Iright","version":"1.0","type":"link"}