{"product_id":"biolegend-635752","title":"Biolegend, 635752, Purified anti-RET Antibody, 100μg","description":"\u003cp\u003eThe proto-oncogene RET encodes a transmembrane tyrosine-protein kinase receptor that is involved in several cellular mechanisms such as proliferation, migration, neuronal navigation, and cell differentiation. RET is important in the development of the nervous system, as well as in the formation of organs and tissues derived from the neural crest. The interaction with the ligand glia cell-line derived neurotrophic factor (GDNF), is vital for promoting cell survival. Conversely, in the absence of GDNF the receptor becomes active and induces apoptosis. Oncogenic activation of RET by either cytogenetic rearrangement or activating mutations, is associated to various diseases such as Hirschsprung disease, central hypoventilation syndrome, and multiple endocrine neoplasia type IIA and type IIB.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of RET protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_3106121 (BioLegend Cat. No. 635751) AB_3106121 (BioLegend Cat. No. 635752)\u003cbr\u003e\nStructure: RET gene encodes a 1114 amino acid protein of around 124 kD.\u003cbr\u003e\nDistribution: Cellular and endosomal membranes\u003cbr\u003e\nFunction: Receptor tyrosine-protein kinase\u003cbr\u003e\nInteraction: PLCG1 and GRB7, PTK2\/FAK1, AIP, ARTN, DOK2, DOK4, DOK5, GFRAL, GFRA1, GDNF\u003cbr\u003e\nLigand\/Receptor: GDNF\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology, Cell Death\u003cbr\u003e\nAntigen References: Novello S, et al. 2023. Oncologist. 28:402-413. Subbiah V, et al. 2020. J Clin Oncol. 38:1209-1221. Regua AT, et al. 2022. Front Oncol. 12:932353. Addeo A, et al. 2023. Pharmacol Ther. 242:108344.\u003cbr\u003e\nGene ID: 5979\u003cbr\u003e\nUniProt: View information about RET on UniProt.org\u003cbr\u003e\nClone: W22020E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CDHF12, CDHR16, PTC, RET51, Proto-oncogene tyrosine-protein kinase receptor Ret, RET receptor Tyrosine Kinase, RET tyrosine kinase receptor, proto-oncogene C-Ret, , RET-ELE1, RET9, Cadherin Family member 12\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866431541417,"sku":"635752","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/biolegend-635752","provider":"Iright","version":"1.0","type":"link"}